DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 421:425

E3 ligase: SPOP

DEGRON score: 0.9979

ASA_SCORE: 97.86

COIL: 0.964

CONS_SCORE: 0.4078

DSS_SCORE: 0.8067

HELIX: 0.0144

FCONS_SCORE: 1.0298

RIG_SCORE: 0.5723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A421G	TCGA-85-A53L	LUSC	TCGA	APTTT	DEG_SPOP_SBC_1	0.754
p.A421G	DO45459	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.754
p.S427Y	TCGA-CK-4948	COAD	TCGA	APTTT	DEG_SPOP_SBC_1	0.7222
p.S427Y	DO10598	COAD	ICGC	APTTT	DEG_SPOP_SBC_1	0.7222
p.E434K	TCGA-EE-A2GO	SKCM	TCGA	APTTT	DEG_SPOP_SBC_1	0.0833
p.E434K	DO37823	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	0.0833
p.T425P	TCGA-QK-A6VB	HNSC	TCGA	APTTT	DEG_SPOP_SBC_1	0.7031
p.T425P	DO219054	HNSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.7031
p.S427P	DO20770	KIRP	ICGC	APTTT	DEG_SPOP_SBC_1	0.7222
p.E419K	DO229058	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.P432T	DO229234	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1389
p.T424I	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.7078
p.T424I	ACH-000951	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.7078
p.T435A	A172	central_nervous_system	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.T435A	COLO-684	endometrium	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.T435A	EW-24	bone	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.T435A	KYSE-70	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.T435A	SK-PN-DW	bone	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.T435A	ABC-1	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.T435A	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.T435A	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.T435A	UM-UC-3	urinary_tract	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.T434P	KG-1	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1556:1560	APTTT	SPOP	0.999	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	777:781	APTTT	SPOP	0.9974	More...
O00257	E3 SUMO-protein ligase CBX4	DEG_SPOP_SBC_1	510:514	APTTT	SPOP	0.9085	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	741:745	APTTT	SPOP	0.9972	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1822:1826	APTTT	SPOP	0.9757	More...
O96005	Cleft lip and palate transmembrane protein 1	DEG_SPOP_SBC_1	626:630	APTTT	SPOP	0.9015	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1323:1327	APTTT	SPOP	0.628	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2466:2470	APTTT	SPOP	0.88	More...
Q6SA08	Testis-specific serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	10:14	APTTT	SPOP	0.7213	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	265:269	APTTT	SPOP	0.9989	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	382:386	APTTT	SPOP	0.9417	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	397:401	APTTT	SPOP	0.7673	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	413:417	APTTT	SPOP	0.8995	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	421:425	APTTT	SPOP	0.9979	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	507:511	APTTT	SPOP	0.9358	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	523:527	APTTT	SPOP	0.9092	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	530:534	APTTT	SPOP	0.9944	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	538:542	APTTT	SPOP	0.9813	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	593:597	APTTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	734:738	APTTT	SPOP	0.6542	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	803:807	APTTT	SPOP	0.9052	More...
Q96AE4	Far upstream element-binding protein 1	DEG_SPOP_SBC_1	559:563	APTTT	SPOP	0.9606	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	800:804	APTTT	SPOP	0.9952	More...
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_SPOP_SBC_1	180:184	APTTT	SPOP	0.926	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	384:388	APTTT	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTTT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of APTTT