DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 593:597

E3 ligase: SPOP

DEGRON score: 0.9962

ASA_SCORE: 98.36

COIL: 0.963

CONS_SCORE: 0.4469

DSS_SCORE: 0.8109

HELIX: 0.0144

FCONS_SCORE: 1.0844

RIG_SCORE: 0.5532

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P605H	TCGA-A4-7583	KIRP	TCGA	APTTT	DEG_SPOP_SBC_1	0.1111
p.P605H	DO20870	KIRP	ICGC	APTTT	DEG_SPOP_SBC_1	0.1111
p.P605L	TCGA-AX-A1CE	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	0.1111
p.P605L	DO42280	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	0.1111
p.E591G	TCGA-B5-A0K9	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	0.2778
p.E591G	DO42097	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.K599Q	TCGA-EE-A3AG	SKCM	TCGA	APTTT	DEG_SPOP_SBC_1	0.2778
p.K599Q	DO37471	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.K599E	DO48444	BLCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.K599E	DO228918	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.K599E	DO228923	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.K599E	DO228978	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.K599E	DO228985	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.K599E	DO229058	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.T597P	DO224628	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.8142
p.T597P	DO228961	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.8142
p.T597P	DO228985	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.8142
p.T597P	DO231186	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.8142
p.T597P	DO228011	SKCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.8142
p.T604A	DO229013	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1389
p.T604A	DO229016	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1389
p.T604A	DO229047	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1389
p.T604A	DO52365	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.1389
p.P600S	DO228944	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.25
p.A585S	DO228944	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1111
p.T601N	D-566MG	central_nervous_system	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2222
p.P603T	SK-NEP-1	kidney	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1667
p.P603T	451Lu	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1667
p.P603T	HCC-15	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1667
p.P603T	U031	kidney	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1667
p.P603T	COLO-824	breast	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1667
p.P603T	MFE-319	endometrium	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1667
p.T585P	CW-2	large_intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1111
p.P597L	SU-DHL-8	NS	COSMIC	APTTT	DEG_SPOP_SBC_1	0.7582
p.A598T	NCI-H1693	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3056
p.A590T	NCI-N87	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3611
p.A590T	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3611
p.E587Q	QIMR-WIL	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1667
p.E589Q	QIMR-WIL	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2222
p.K590E	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3611
p.A592T	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3056
p.A592T	NCI-N87	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3056
p.T603N	D-566MG	central_nervous_system	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1667
p.T587P	CW-2	large_intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1667
p.P599L	SU-DHL-8	NS	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2778
p.K588E	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1944
p.A600T	NCI-H1693	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1556:1560	APTTT	SPOP	0.999	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	777:781	APTTT	SPOP	0.9974	More...
O00257	E3 SUMO-protein ligase CBX4	DEG_SPOP_SBC_1	510:514	APTTT	SPOP	0.9085	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	741:745	APTTT	SPOP	0.9972	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1822:1826	APTTT	SPOP	0.9757	More...
O96005	Cleft lip and palate transmembrane protein 1	DEG_SPOP_SBC_1	626:630	APTTT	SPOP	0.9015	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1323:1327	APTTT	SPOP	0.628	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2466:2470	APTTT	SPOP	0.88	More...
Q6SA08	Testis-specific serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	10:14	APTTT	SPOP	0.7213	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	265:269	APTTT	SPOP	0.9989	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	382:386	APTTT	SPOP	0.9417	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	397:401	APTTT	SPOP	0.7673	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	413:417	APTTT	SPOP	0.8995	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	421:425	APTTT	SPOP	0.9979	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	507:511	APTTT	SPOP	0.9358	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	523:527	APTTT	SPOP	0.9092	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	530:534	APTTT	SPOP	0.9944	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	538:542	APTTT	SPOP	0.9813	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	593:597	APTTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	734:738	APTTT	SPOP	0.6542	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	803:807	APTTT	SPOP	0.9052	More...
Q96AE4	Far upstream element-binding protein 1	DEG_SPOP_SBC_1	559:563	APTTT	SPOP	0.9606	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	800:804	APTTT	SPOP	0.9952	More...
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_SPOP_SBC_1	180:184	APTTT	SPOP	0.926	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	384:388	APTTT	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTTT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of APTTT