DegronMD

Uniprot ID: O75179

Source protein: Ankyrin repeat domain-containing protein 17

Source gene: ANKRD17

Class: DEG_SPOP_SBC_1

Location: 1822:1826

E3 ligase: SPOP

DEGRON score: 0.9757

ASA_SCORE: 78.2

COIL: 0.8634

CONS_SCORE: 0.4554

DSS_SCORE: 0.458

HELIX: 0.0322

FCONS_SCORE: 1.0162

RIG_SCORE: 0.6657

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1819A	TCGA-78-7220	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	0.25
p.S1821L	TCGA-85-A4CL	LUSC	TCGA	APTTT	DEG_SPOP_SBC_1	0.3056
p.A1822V	TCGA-HU-A4H5	STAD	TCGA	APTTT	DEG_SPOP_SBC_1	0.5825
p.I1818R	TCGA-HU-A4H5	STAD	TCGA	APTTT	DEG_SPOP_SBC_1	0.2222
p.R1835C	DO7816	COAD	ICGC	APTTT	DEG_SPOP_SBC_1	0.0833
p.R1835H	DO8264	COAD	ICGC	APTTT	DEG_SPOP_SBC_1	0.0833
p.V1833A	DO233791	GACA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1389
p.V1833M	DO14378	HNSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.1389
p.P1830T	DO228948	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.2222
p.P1821T	DO229018	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.3056
p.H1836Y	DO37519	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	0.1667
p.A1824S	DO42280	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	0.7588
p.S1827L	DO41799	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	0.3056
p.P1830H	DO42472	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	0.2222
p.P1815H	DO43995	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	0.1389
p.S1813T	SIDM00845	Burkitt's Lymphoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.0833
p.S1813T	SIDM00035	Thyroid Gland Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.0833
p.S1813T	SIDM00461	Acute Myeloid Leukemia	GDSC	APTTT	DEG_SPOP_SBC_1	0.0833
p.S1813T	SIDM01519	Head and Neck Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.0833
p.S1813T	ACH-000786	Lymphoma	CCLE	APTTT	DEG_SPOP_SBC_1	0.0833
p.S1813T	ACH-000992	Head and Neck Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.0833
p.S1813T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0833
p.S1813T	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0833
p.N1829K	SIDM00264	Ewing's Sarcoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.25
p.N1829K	ACH-002105	Bone Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.25
p.N1829K	ES4	bone	COSMIC	APTTT	DEG_SPOP_SBC_1	0.25
p.G1819W	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.25
p.G1819W	ACH-000888	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.25
p.G1819W	NCI-H1793	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	0.25
p.P1828A	HSC-2	upper_aerodigestive_tract	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2778
p.P1813S	ONS-76	central_nervous_system	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0833
p.E1825K	MFE-319	endometrium	COSMIC	APTTT	DEG_SPOP_SBC_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1556:1560	APTTT	SPOP	0.999	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	777:781	APTTT	SPOP	0.9974	More...
O00257	E3 SUMO-protein ligase CBX4	DEG_SPOP_SBC_1	510:514	APTTT	SPOP	0.9085	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	741:745	APTTT	SPOP	0.9972	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1822:1826	APTTT	SPOP	0.9757	More...
O96005	Cleft lip and palate transmembrane protein 1	DEG_SPOP_SBC_1	626:630	APTTT	SPOP	0.9015	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1323:1327	APTTT	SPOP	0.628	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2466:2470	APTTT	SPOP	0.88	More...
Q6SA08	Testis-specific serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	10:14	APTTT	SPOP	0.7213	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	265:269	APTTT	SPOP	0.9989	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	382:386	APTTT	SPOP	0.9417	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	397:401	APTTT	SPOP	0.7673	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	413:417	APTTT	SPOP	0.8995	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	421:425	APTTT	SPOP	0.9979	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	507:511	APTTT	SPOP	0.9358	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	523:527	APTTT	SPOP	0.9092	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	530:534	APTTT	SPOP	0.9944	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	538:542	APTTT	SPOP	0.9813	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	593:597	APTTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	734:738	APTTT	SPOP	0.6542	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	803:807	APTTT	SPOP	0.9052	More...
Q96AE4	Far upstream element-binding protein 1	DEG_SPOP_SBC_1	559:563	APTTT	SPOP	0.9606	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	800:804	APTTT	SPOP	0.9952	More...
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_SPOP_SBC_1	180:184	APTTT	SPOP	0.926	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	384:388	APTTT	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTTT

Degron related mutations and impact score

Drug responses associated with ANKRD17 mutations

All proteins holding degron of APTTT