DegronMD

Uniprot ID: Q96HA1

Source protein: Nuclear envelope pore membrane protein POM 121

Source gene: POM121

Class: DEG_SPOP_SBC_1

Location: 800:804

E3 ligase: SPOP

DEGRON score: 0.9952

ASA_SCORE: 85.94

COIL: 0.943

CONS_SCORE: 0.5086

DSS_SCORE: 0.4917

HELIX: 0.0216

FCONS_SCORE: 0.7992

RIG_SCORE: 0.7538

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F799I	TCGA-20-0991	OV	TCGA	APTTT	DEG_SPOP_SBC_1	0.3056
p.F799I	DO31949	OV	ICGC	APTTT	DEG_SPOP_SBC_1	0.3056
p.G809R	TCGA-3N-A9WC	SKCM	TCGA	APTTT	DEG_SPOP_SBC_1	0.1944
p.G809R	DO51234	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	0.1944
p.P790S	TCGA-AO-A128	BRCA	TCGA	APTTT	DEG_SPOP_SBC_1	0.0556
p.P790S	DO5326	BRCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.0556
p.T804I	TCGA-AP-A1DK	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	0.7078
p.T804I	DO42033	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	0.7078
p.S806C	TCGA-B5-A11R	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	0.2778
p.S806C	DO43787	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.F808C	TCGA-DX-A6YS	SARC	TCGA	APTTT	DEG_SPOP_SBC_1	0.2222
p.F808C	DO220005	SARC	ICGC	APTTT	DEG_SPOP_SBC_1	0.2222
p.T814I	TCGA-EE-A2MI	SKCM	TCGA	APTTT	DEG_SPOP_SBC_1	0.0556
p.T814I	DO37531	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	0.0556
p.S795Y	TCGA-L9-A7SV	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	0.1944
p.S795Y	DO49875	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	0.1944
p.A803V	DO222731	MELA	ICGC	APTTT	DEG_SPOP_SBC_1	0.6936
p.A810G	DO229250	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1667
p.Q793E	ACH-000427	Gastric Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.1389
p.Q793E	ACH-000515	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.1389
p.Q793E	ACH-000612	Lymphoma	CCLE	APTTT	DEG_SPOP_SBC_1	0.1389
p.Q793E	ACH-000621	Breast Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.1389
p.K792N	ACH-000977	lymph_node	CCLE	APTTT	DEG_SPOP_SBC_1	0.2222
p.A802S	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1556:1560	APTTT	SPOP	0.999	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	777:781	APTTT	SPOP	0.9974	More...
O00257	E3 SUMO-protein ligase CBX4	DEG_SPOP_SBC_1	510:514	APTTT	SPOP	0.9085	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	741:745	APTTT	SPOP	0.9972	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1822:1826	APTTT	SPOP	0.9757	More...
O96005	Cleft lip and palate transmembrane protein 1	DEG_SPOP_SBC_1	626:630	APTTT	SPOP	0.9015	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1323:1327	APTTT	SPOP	0.628	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2466:2470	APTTT	SPOP	0.88	More...
Q6SA08	Testis-specific serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	10:14	APTTT	SPOP	0.7213	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	265:269	APTTT	SPOP	0.9989	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	382:386	APTTT	SPOP	0.9417	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	397:401	APTTT	SPOP	0.7673	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	413:417	APTTT	SPOP	0.8995	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	421:425	APTTT	SPOP	0.9979	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	507:511	APTTT	SPOP	0.9358	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	523:527	APTTT	SPOP	0.9092	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	530:534	APTTT	SPOP	0.9944	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	538:542	APTTT	SPOP	0.9813	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	593:597	APTTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	734:738	APTTT	SPOP	0.6542	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	803:807	APTTT	SPOP	0.9052	More...
Q96AE4	Far upstream element-binding protein 1	DEG_SPOP_SBC_1	559:563	APTTT	SPOP	0.9606	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	800:804	APTTT	SPOP	0.9952	More...
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_SPOP_SBC_1	180:184	APTTT	SPOP	0.926	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	384:388	APTTT	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTTT

Degron related mutations and impact score

Drug responses associated with POM121 mutations

All proteins holding degron of APTTT