DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
APTTT
Uniprot ID:
Q92954
Source protein:
Proteoglycan 4
Source gene:
PRG4
Class:
DEG_SPOP_SBC_1
Location:
803:807
E3 ligase:
SPOP
DEGRON score:
0.9052
ASA_SCORE:
93.1
COIL:
0.957
CONS_SCORE:
0.1583
DSS_SCORE:
0.7874
HELIX:
0.0152
FCONS_SCORE:
0.7478
RIG_SCORE:
0.5936
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T807N
TCGA-35-5375
LUAD
TCGA
APTTT
DEG_SPOP_SBC_1
0.7055
p.T807N
DO25290
LUAD
ICGC
APTTT
DEG_SPOP_SBC_1
0.7055
p.S815T
SIDM00669
Pancreatic Carcinoma
GDSC
APTTT
DEG_SPOP_SBC_1
0.5556
p.S815T
SIDM00721
Small Cell Lung Carcinoma
GDSC
APTTT
DEG_SPOP_SBC_1
0.5556
p.T808A
EN
endometrium
COSMIC
APTTT
DEG_SPOP_SBC_1
0.3056
p.E801K
TCGA-D1-A17Q
UCEC
TCGA
APTTT
DEG_SPOP_SBC_1
0.2778
p.E801K
TCGA-W3-AA1V
SKCM
TCGA
APTTT
DEG_SPOP_SBC_1
0.2778
p.E801K
DO51276
SKCM
ICGC
APTTT
DEG_SPOP_SBC_1
0.2778
p.E801K
DO41903
UCEC
ICGC
APTTT
DEG_SPOP_SBC_1
0.2778
p.G809E
DO233705
GACA
ICGC
APTTT
DEG_SPOP_SBC_1
0.2778
p.G809E
DO227501
LAML
ICGC
APTTT
DEG_SPOP_SBC_1
0.2778
p.G809E
DO227513
LAML
ICGC
APTTT
DEG_SPOP_SBC_1
0.2778
p.G809E
DO224619
LUSC
ICGC
APTTT
DEG_SPOP_SBC_1
0.2778
p.G809E
DO229208
THCA
ICGC
APTTT
DEG_SPOP_SBC_1
0.2778
p.K796E
SIDM00218
Thyroid Gland Carcinoma
GDSC
APTTT
DEG_SPOP_SBC_1
0.25
p.K796E
SIDM00900
Non-Cancerous
GDSC
APTTT
DEG_SPOP_SBC_1
0.25
p.P799H
TCGA-PG-A917
UCEC
TCGA
APTTT
DEG_SPOP_SBC_1
0.2222
p.P799H
DO52424
UCEC
ICGC
APTTT
DEG_SPOP_SBC_1
0.2222
p.A798V
TCGA-FI-A2D5
UCEC
TCGA
APTTT
DEG_SPOP_SBC_1
0.1944
p.A798V
DO41331
UCEC
ICGC
APTTT
DEG_SPOP_SBC_1
0.1944
p.K817T
TCGA-AX-A0J0
UCEC
TCGA
APTTT
DEG_SPOP_SBC_1
0.1667
p.K817T
DO41133
UCEC
ICGC
APTTT
DEG_SPOP_SBC_1
0.1667
Showing 1 to 22 of 22 entries
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Drug responses associated with PRG4 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
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All proteins holding degron of APTTT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75179
Ankyrin repeat domain-containing protein 17
DEG_SPOP_SBC_1
1822:1826
APTTT
SPOP
0.9757
More...
O96005
Cleft lip and palate transmembrane protein 1
DEG_SPOP_SBC_1
626:630
APTTT
SPOP
0.9015
More...
O00257
E3 SUMO-protein ligase CBX4
DEG_SPOP_SBC_1
510:514
APTTT
SPOP
0.9085
More...
Q5T4S7
E3 ubiquitin-protein ligase UBR4
DEG_SPOP_SBC_1
2466:2470
APTTT
SPOP
0.88
More...
Q96AE4
Far upstream element-binding protein 1
DEG_SPOP_SBC_1
559:563
APTTT
SPOP
0.9606
More...
Q9Y5Y7
Lymphatic vessel endothelial hyaluronic acid receptor 1
DEG_SPOP_SBC_1
180:184
APTTT
SPOP
0.926
More...
O15054
Lysine-specific demethylase 6B
DEG_SPOP_SBC_1
741:745
APTTT
SPOP
0.9972
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1323:1327
APTTT
SPOP
0.628
More...
Q96HA1
Nuclear envelope pore membrane protein POM 121
DEG_SPOP_SBC_1
800:804
APTTT
SPOP
0.9952
More...
A8CG34
Nuclear envelope pore membrane protein POM 121C
DEG_SPOP_SBC_1
777:781
APTTT
SPOP
0.9974
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
382:386
APTTT
SPOP
0.9417
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
397:401
APTTT
SPOP
0.7673
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
413:417
APTTT
SPOP
0.8995
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
421:425
APTTT
SPOP
0.9979
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
507:511
APTTT
SPOP
0.9358
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
523:527
APTTT
SPOP
0.9092
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
530:534
APTTT
SPOP
0.9944
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
538:542
APTTT
SPOP
0.9813
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
593:597
APTTT
SPOP
0.9962
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
734:738
APTTT
SPOP
0.6542
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
803:807
APTTT
SPOP
0.9052
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SPOP_SBC_1
384:388
APTTT
SPOP
0.9984
More...
A1L4H1
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
DEG_SPOP_SBC_1
1556:1560
APTTT
SPOP
0.999
More...
Q6SA08
Testis-specific serine/threonine-protein kinase 4
DEG_SPOP_SBC_1
10:14
APTTT
SPOP
0.7213
More...
Q6UXF1
Transmembrane protein 108
DEG_SPOP_SBC_1
265:269
APTTT
SPOP
0.9989
More...
Showing 1 to 25 of 25 entries
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