DegronMD

Uniprot ID: Q6UXF1

Source protein: Transmembrane protein 108

Source gene: TMEM108

Class: DEG_SPOP_SBC_1

Location: 158:162

E3 ligase: SPOP

DEGRON score: 0.8778

ASA_SCORE: 113.1

COIL: 0.957

CONS_SCORE: 0.5066

DSS_SCORE: 0.9381

HELIX: 0.013

FCONS_SCORE: 0.9571

RIG_SCORE: 0.5871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R159H	TCGA-AA-3685	COAD	TCGA	PRTTT	DEG_SPOP_SBC_1	0.7133
p.R159H	DO8047	COAD	ICGC	PRTTT	DEG_SPOP_SBC_1	0.7133
p.R159H	DO224596	PACA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.7133
p.P168S	TCGA-AP-A059	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.1667
p.P168S	DO41361	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.1667
p.A149G	TCGA-B5-A11H	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.0833
p.A149G	DO42825	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.0833
p.G148R	TCGA-EE-A2GU	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.0556
p.G148R	DO37639	SKCM	ICGC	PRTTT	DEG_SPOP_SBC_1	0.0556
p.R163C	DO230335	COCA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.3056
p.R163C	SIDM00238	Ovarian Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.3056
p.R163C	ACH-000947	Ovarian Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	0.3056
p.R163C	OVK-18	ovary	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.3056
p.A156V	DO233270	GACA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.2778
p.G170V	DO23262	LINC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.1111
p.P157H	SIDM00086	Kidney Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.3056
p.P157H	SIDM00176	Chondrosarcoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.3056
p.P157H	CHSA8926	bone	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.3056
p.P157H	RXF393	kidney	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.3056
p.R163H	SIDM01752	Pancreatic Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.3056
p.P158S	ACH-000799	Skin Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	0.6752
p.T155P	ACH-002659	Colon/Colorectal Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00743	Serine/threonine-protein phosphatase 6 catalytic subunit	DEG_SPOP_SBC_1	297:301	PRTTT	SPOP	0.843	More...
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	547:551	PRTTT	SPOP	0.9897	More...
P11586	C-1-tetrahydrofolate synthase, cytoplasmic	DEG_SPOP_SBC_1	73:77	PRTTT	SPOP	0.9103	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4130:4134	PRTTT	SPOP	0.638	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	158:162	PRTTT	SPOP	0.8778	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	138:142	PRTTT	SPOP	0.6495	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons