DegronMD - Q76N32(CEP68)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A149D	TCGA-AP-A059	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1389
p.A149D	DO41361	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1389
p.T141A	TCGA-FD-A43N	BLCA	TCGA	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7139
p.T141A	DO502	BLCA	ICGC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7139
p.L544V	DO49976	CESC	ICGC	PSSSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.0833
p.D537H	DO234225	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.2778
p.E129K	DO229480	LAML	ICGC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0833
p.E129K	SIDM00781	Colorectal Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0833
p.E129K	SIDM00780	Colorectal Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0833
p.E129K	SIDM01753	Gastric Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0833
p.S543C	DO45005	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1111
p.Q542P	DO52258	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1389
p.T140R	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.T140R	SIDM00078	Oral Cavity Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.T140R	SIDM00426	Rhabdomyosarcoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.T140R	SIDM00885	Breast Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.T140R	SIDM00820	Kidney Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.T140R	SIDM00445	Esophageal Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.T140R	SIDM00874	Breast Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.T140R	SIDM00085	Glioma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.T140R	SIDM00847	Rhabdomyosarcoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.T140R	SIDM00814	Other Solid Cancers	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.T140R	SIDM01229	Neuroblastoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.T140R	SIDM00100	Mesothelioma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7876
p.S529Y	SIDM00577	Neuroblastoma	GDSC	PSSSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.2778
p.S529Y	ACH-001603	Neuroblastoma	CCLE	PSSSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.2778
p.S529Y	NH-12	autonomic ganglia	COSMIC	PSSSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.2778
p.T142A	SIDM00523	Small Cell Lung Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7139
p.T142A	ACH-000698	Lung Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7139
p.T142A	DMS-53	lung	COSMIC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7139
p.S524R	SIDM00965	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1389
p.S524R	NCI-H446	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1389
p.S136R	NCI-H446	lung	COSMIC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation blocking phosphorylation signal	0.7222
p.S141Y	NH-12	autonomic ganglia	COSMIC	PRTTT	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.712

Kaplan plot for CEP68 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP68

UniProt ID: Q76N32

Entrez ID: 23177

Protein name: Centrosomal protein of 68 kDa (Cep68)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP68 in