DegronMD

Uniprot ID: Q76N32

Source protein: Centrosomal protein of 68 kDa

Source gene: CEP68

Class: DEG_SPOP_SBC_1

Location: 138:142

E3 ligase: SPOP

DEGRON score: 0.6495

ASA_SCORE: 92.48

COIL: 0.895

CONS_SCORE: 0.4684

DSS_SCORE: 0.5535

HELIX: 0.0266

FCONS_SCORE: 0.9105

RIG_SCORE: 0.7021

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A149D	TCGA-AP-A059	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.1389
p.A149D	DO41361	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.1389
p.T141A	TCGA-FD-A43N	BLCA	TCGA	PRTTT	DEG_SPOP_SBC_1	0.7139
p.T141A	DO502	BLCA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.7139
p.E129K	DO229480	LAML	ICGC	PRTTT	DEG_SPOP_SBC_1	0.0833
p.E129K	SIDM00781	Colorectal Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.0833
p.E129K	SIDM00780	Colorectal Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.0833
p.E129K	SIDM01753	Gastric Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.0833
p.T140R	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T140R	SIDM00078	Oral Cavity Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T140R	SIDM00426	Rhabdomyosarcoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T140R	SIDM00885	Breast Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T140R	SIDM00820	Kidney Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T140R	SIDM00445	Esophageal Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T140R	SIDM00874	Breast Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T140R	SIDM00085	Glioma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T140R	SIDM00847	Rhabdomyosarcoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T140R	SIDM00814	Other Solid Cancers	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T140R	SIDM01229	Neuroblastoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T140R	SIDM00100	Mesothelioma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7876
p.T142A	SIDM00523	Small Cell Lung Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.7139
p.T142A	ACH-000698	Lung Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	0.7139
p.T142A	DMS-53	lung	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.7139
p.S136R	NCI-H446	lung	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.7222
p.S141Y	NH-12	autonomic_ganglia	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00743	Serine/threonine-protein phosphatase 6 catalytic subunit	DEG_SPOP_SBC_1	297:301	PRTTT	SPOP	0.843	More...
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	547:551	PRTTT	SPOP	0.9897	More...
P11586	C-1-tetrahydrofolate synthase, cytoplasmic	DEG_SPOP_SBC_1	73:77	PRTTT	SPOP	0.9103	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4130:4134	PRTTT	SPOP	0.638	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	158:162	PRTTT	SPOP	0.8778	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	138:142	PRTTT	SPOP	0.6495	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTTT

Degron related mutations and impact score

Drug responses associated with CEP68 mutations

All proteins holding degron of PRTTT