DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 4130:4134

E3 ligase: SPOP

DEGRON score: 0.638

ASA_SCORE: 91.64

COIL: 0.7114

CONS_SCORE: 0.5315

DSS_SCORE: 0.2939

HELIX: 0.019

FCONS_SCORE: 0.8345

RIG_SCORE: 0.8045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C4135S	TCGA-95-7043	LUAD	TCGA	PRTTT	DEG_SPOP_SBC_1	0.3056
p.C4135S	DO24739	LUAD	ICGC	PRTTT	DEG_SPOP_SBC_1	0.3056
p.G4137R	TCGA-D3-A51R	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.25
p.G4137R	TCGA-E7-A4IJ	BLCA	TCGA	PRTTT	DEG_SPOP_SBC_1	0.25
p.G4137R	DO453	BLCA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.25
p.G4137R	DO47480	SKCM	ICGC	PRTTT	DEG_SPOP_SBC_1	0.25
p.P4123L	TCGA-EE-A3AF	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.1389
p.P4123L	DO37911	SKCM	ICGC	PRTTT	DEG_SPOP_SBC_1	0.1389
p.T4143M	TCGA-EO-A22R	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.0833
p.T4143M	DO42713	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.0833
p.A4144S	DO229026	LICA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.0556
p.G4137E	DO229456	SKCA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.25
p.F4136L	DO229224	THCA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.2778
p.T4143S	SIDM01126	Small Cell Lung Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.0833
p.T4143S	SIDM01147	Gastric Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.0833
p.S4121G	SIDM00094	Kidney Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.0833
p.S4121G	ACH-002199	Kidney Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	0.0833
p.S4121G	SN12C	kidney	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00743	Serine/threonine-protein phosphatase 6 catalytic subunit	DEG_SPOP_SBC_1	297:301	PRTTT	SPOP	0.843	More...
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	547:551	PRTTT	SPOP	0.9897	More...
P11586	C-1-tetrahydrofolate synthase, cytoplasmic	DEG_SPOP_SBC_1	73:77	PRTTT	SPOP	0.9103	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4130:4134	PRTTT	SPOP	0.638	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	158:162	PRTTT	SPOP	0.8778	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	138:142	PRTTT	SPOP	0.6495	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons