DegronMD

Uniprot ID: O00743

Source protein: Serine/threonine-protein phosphatase 6 catalytic subunit

Source gene: PPP6C

Class: DEG_SPOP_SBC_1

Location: 297:301

E3 ligase: SPOP

DEGRON score: 0.843

ASA_SCORE: 98.08

COIL: 0.9472

CONS_SCORE: 0.3693

DSS_SCORE: 0.6408

HELIX: 0.0216

FCONS_SCORE: 0.8091

RIG_SCORE: 0.7507

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R301C	TCGA-18-3409	LUSC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301C	TCGA-BF-A1PX	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301C	TCGA-BF-A5EO	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301C	TCGA-D3-A8GJ	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301C	TCGA-D3-A8GO	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301C	TCGA-DA-A3F8	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301C	TCGA-EB-A3XB	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301C	TCGA-EB-A5SG	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301C	TCGA-EE-A2GM	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301C	TCGA-FS-A1ZC	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301C	TCGA-W3-A825	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301C	TCGA-W3-AA21	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8301
p.R301H	TCGA-AX-A2HC	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8244
p.R301H	TCGA-B5-A3FC	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8244
p.P296L	TCGA-DA-A1I1	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.3056
p.P296S	TCGA-EB-A3XC	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.3056
p.S307L	TCGA-FS-A1ZH	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.1667
p.S307L	TCGA-FS-A1ZW	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.1667
p.N297T	TCGA-IB-7651	PAAD	TCGA	PRTTT	DEG_SPOP_SBC_1	0.7055
p.P297R	ACH-000319	Lung Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	0.7512
p.Y303H	ACH-000978	Endometrial/Uterine Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	0.2778
p.Y303H	EN	endometrium	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00743	Serine/threonine-protein phosphatase 6 catalytic subunit	DEG_SPOP_SBC_1	297:301	PRTTT	SPOP	0.843	More...
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	547:551	PRTTT	SPOP	0.9897	More...
P11586	C-1-tetrahydrofolate synthase, cytoplasmic	DEG_SPOP_SBC_1	73:77	PRTTT	SPOP	0.9103	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4130:4134	PRTTT	SPOP	0.638	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	158:162	PRTTT	SPOP	0.8778	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	138:142	PRTTT	SPOP	0.6495	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons