DegronMD

Uniprot ID: P11586

Source protein: C-1-tetrahydrofolate synthase, cytoplasmic

Source gene: MTHFD1

Class: DEG_SPOP_SBC_1

Location: 73:77

E3 ligase: SPOP

DEGRON score: 0.9103

ASA_SCORE: 80.5

COIL: 0.95

CONS_SCORE: 0.3679

DSS_SCORE: 0.2849

HELIX: 0.0124

FCONS_SCORE: 1.0157

RIG_SCORE: 0.7873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M82I	TCGA-66-2781	LUSC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.1944
p.M82I	DO26422	LUSC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.1944
p.S87C	TCGA-85-A4CL	LUSC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.0556
p.S87C	DO45454	LUSC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.0556
p.S79F	TCGA-A5-A2K5	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.2778
p.S79F	TCGA-DU-6392	LGG	TCGA	PRTTT	DEG_SPOP_SBC_1	0.2778
p.S79F	DO22237	LGG	ICGC	PRTTT	DEG_SPOP_SBC_1	0.2778
p.S79F	DO41379	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.2778
p.S79C	TCGA-C8-A274	BRCA	TCGA	PRTTT	DEG_SPOP_SBC_1	0.2778
p.S79C	DO5675	BRCA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.2778
p.T76I	TCGA-EE-A2MR	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	0.8189
p.T76I	DO37819	SKCM	ICGC	PRTTT	DEG_SPOP_SBC_1	0.8189
p.E80G	SIDM00217	Colorectal Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	0.25
p.E80G	SNU-1040	large_intestine	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.25
p.K77E	ACH-000166	Leukemia	CCLE	PRTTT	DEG_SPOP_SBC_1	0.7022
p.Q82L	ACH-002282	Neuroblastoma	CCLE	PRTTT	DEG_SPOP_SBC_1	0.1944
p.Q82L	NB17	autonomic_ganglia	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.1944
p.Q82H	ACH-002282	Neuroblastoma	CCLE	PRTTT	DEG_SPOP_SBC_1	0.1944
p.Q82H	NB17	autonomic_ganglia	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00743	Serine/threonine-protein phosphatase 6 catalytic subunit	DEG_SPOP_SBC_1	297:301	PRTTT	SPOP	0.843	More...
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	547:551	PRTTT	SPOP	0.9897	More...
P11586	C-1-tetrahydrofolate synthase, cytoplasmic	DEG_SPOP_SBC_1	73:77	PRTTT	SPOP	0.9103	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4130:4134	PRTTT	SPOP	0.638	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	158:162	PRTTT	SPOP	0.8778	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	138:142	PRTTT	SPOP	0.6495	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons