DegronMD

Uniprot ID: O14490

Source protein: Disks large-associated protein 1

Source gene: DLGAP1

Class: DEG_SPOP_SBC_1

Location: 547:551

E3 ligase: SPOP

DEGRON score: 0.9897

ASA_SCORE: 108.1

COIL: 0.9438

CONS_SCORE: 0.4248

DSS_SCORE: 0.6239

HELIX: 0.0232

FCONS_SCORE: 0.9205

RIG_SCORE: 0.7171

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P543H	TCGA-A5-A0G2	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.2222
p.R548I	TCGA-B5-A0JY	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.6991
p.R548I	TCGA-BS-A0UF	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.6991
p.R548K	TCGA-FI-A2D0	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	0.6126
p.R540Q	DO10308	COAD	ICGC	PRTTT	DEG_SPOP_SBC_1	0.25
p.K538N	DO7783	COAD	ICGC	PRTTT	DEG_SPOP_SBC_1	0.0833
p.V543A	DO222864	COCA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.2222
p.A551G	DO223060	ESCA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.754
p.G537A	DO11489	GBM	ICGC	PRTTT	DEG_SPOP_SBC_1	0.5
p.T541I	DO48516	KIRP	ICGC	PRTTT	DEG_SPOP_SBC_1	0.6111
p.T541I	CW-2	large_intestine	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.6111
p.G537E	DO45163	LIRI	ICGC	PRTTT	DEG_SPOP_SBC_1	0.5
p.G537E	DO37406	SKCM	ICGC	PRTTT	DEG_SPOP_SBC_1	0.5
p.R558K	DO48899	PBCA	ICGC	PRTTT	DEG_SPOP_SBC_1	0.1389
p.A542T	DO52402	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.1944
p.K553I	DO41536	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.2778
p.Q547L	DO52424	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.7765
p.G544D	DO41199	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	0.25
p.N540S	NCI-H1048	lung	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.25
p.T539I	CW-2	large_intestine	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.2222
p.N546S	NCI-H1048	lung	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.3056
p.N554S	NCI-H1048	lung	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.25
p.T555I	CW-2	large_intestine	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.2222
p.G556R	NCI-H630	large_intestine	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.1944
p.T549I	CW-2	large_intestine	COSMIC	PRTTT	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00743	Serine/threonine-protein phosphatase 6 catalytic subunit	DEG_SPOP_SBC_1	297:301	PRTTT	SPOP	0.843	More...
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	547:551	PRTTT	SPOP	0.9897	More...
P11586	C-1-tetrahydrofolate synthase, cytoplasmic	DEG_SPOP_SBC_1	73:77	PRTTT	SPOP	0.9103	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4130:4134	PRTTT	SPOP	0.638	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	158:162	PRTTT	SPOP	0.8778	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	138:142	PRTTT	SPOP	0.6495	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons