DegronMD - O00743(PPP6C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R301C	TCGA-18-3409	LUSC	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301C	TCGA-BF-A1PX	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301C	TCGA-BF-A5EO	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301C	TCGA-D3-A8GJ	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301C	TCGA-D3-A8GO	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301C	TCGA-DA-A3F8	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301C	TCGA-EB-A3XB	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301C	TCGA-EB-A5SG	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301C	TCGA-EE-A2GM	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301C	TCGA-FS-A1ZC	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301C	TCGA-W3-A825	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301C	TCGA-W3-AA21	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8301
p.R301H	TCGA-AX-A2HC	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8244
p.R301H	TCGA-B5-A3FC	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.8244
p.P296L	TCGA-DA-A1I1	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.3056
p.P296S	TCGA-EB-A3XC	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.3056
p.S307L	TCGA-FS-A1ZH	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.S307L	TCGA-FS-A1ZW	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.N297T	TCGA-IB-7651	PAAD	TCGA	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.7055
p.P297R	ACH-000319	Lung Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.7512
p.Y303H	ACH-000978	Endometrial/Uterine Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.2778
p.Y303H	EN	endometrium	COSMIC	PRTTT	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.2778

Kaplan plot for PPP6C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP6C

UniProt ID: O00743

Entrez ID: 5537

Protein name: Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP6C in