DegronMD

Uniprot ID: Q6UXF1

Source protein: Transmembrane protein 108

Source gene: TMEM108

Class: DEG_SPOP_SBC_1

Location: 54:58

E3 ligase: SPOP

DEGRON score: 0.9327

ASA_SCORE: 94.14

COIL: 0.9494

CONS_SCORE: 0.3546

DSS_SCORE: 0.6656

HELIX: 0.0316

FCONS_SCORE: 0.9308

RIG_SCORE: 0.5998

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A53T	TCGA-AJ-A3EK	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	0.3056
p.A53T	DO41584	UCEC	ICGC	PHSST	DEG_SPOP_SBC_1	0.3056
p.S62Y	TCGA-BK-A6W3	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	0.2222
p.S62Y	DO50076	UCEC	ICGC	PHSST	DEG_SPOP_SBC_1	0.2222
p.H55Y	TCGA-E5-A4U1	BLCA	TCGA	PHSST	DEG_SPOP_SBC_1	0.6118
p.H55Y	DO44061	BLCA	ICGC	PHSST	DEG_SPOP_SBC_1	0.6118
p.E65Q	DO51866	BLCA	ICGC	PHSST	DEG_SPOP_SBC_1	0.1389
p.E65K	DO14566	HNSC	ICGC	PHSST	DEG_SPOP_SBC_1	0.1389
p.P54H	DO50966	LICA	ICGC	PHSST	DEG_SPOP_SBC_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68D10	Protein SPT2 homolog	DEG_SPOP_SBC_1	315:319	PHSST	SPOP	0.9783	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	54:58	PHSST	SPOP	0.9327	More...
Q9C0B9	Zinc finger CCHC domain-containing protein 2	DEG_SPOP_SBC_1	801:805	PHSST	SPOP	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons