DegronMD

Uniprot ID: Q68D10

Source protein: Protein SPT2 homolog

Source gene: SPTY2D1

Class: DEG_SPOP_SBC_1

Location: 315:319

E3 ligase: SPOP

DEGRON score: 0.9783

ASA_SCORE: 91.54

COIL: 0.9236

CONS_SCORE: 0.3586

DSS_SCORE: 0.7246

HELIX: 0.0422

FCONS_SCORE: 1.1562

RIG_SCORE: 0.5165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A312T	TCGA-32-2616	GBM	TCGA	PHSST	DEG_SPOP_SBC_1	0.25
p.A312T	DO13462	GBM	ICGC	PHSST	DEG_SPOP_SBC_1	0.25
p.A329T	TCGA-AX-A0J1	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	0.0556
p.A329T	DO41199	UCEC	ICGC	PHSST	DEG_SPOP_SBC_1	0.0556
p.K314E	TCGA-E6-A1LX	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	0.3056
p.K314E	DO41020	UCEC	ICGC	PHSST	DEG_SPOP_SBC_1	0.3056
p.D305N	TCGA-EO-A3AZ	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	0.0556
p.D305N	DO50078	UCEC	ICGC	PHSST	DEG_SPOP_SBC_1	0.0556
p.S318C	DO23130	LINC	ICGC	PHSST	DEG_SPOP_SBC_1	0.7541
p.T319I	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PHSST	DEG_SPOP_SBC_1	0.7078
p.T319I	ACH-000816	Lung Cancer	CCLE	PHSST	DEG_SPOP_SBC_1	0.7078
p.T319I	ACH-000916	Lung Cancer	CCLE	PHSST	DEG_SPOP_SBC_1	0.7078
p.T319I	NCI-H1573	lung	COSMIC	PHSST	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68D10	Protein SPT2 homolog	DEG_SPOP_SBC_1	315:319	PHSST	SPOP	0.9783	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	54:58	PHSST	SPOP	0.9327	More...
Q9C0B9	Zinc finger CCHC domain-containing protein 2	DEG_SPOP_SBC_1	801:805	PHSST	SPOP	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons