DegronMD - Q9C0B9(ZCCHC2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T672A	TCGA-91-6831	LUAD	TCGA	DSGNPST	DEG_SCF_TRCP1_1	666:672	Mutation altering degron motif	0.6028
p.R814G	TCGA-A5-A0GP	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.0833
p.T805N	TCGA-AJ-A3EK	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	801:805	Mutation altering degron motif	0.7055
p.G668V	TCGA-AP-A1DK	UCEC	TCGA	DSGNPST	DEG_SCF_TRCP1_1	666:672	Mutation altering degron motif	0.7532
p.R349Q	TCGA-B5-A11E	UCEC	TCGA	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation altering degron motif	0.7329
p.R349Q	DO41644	UCEC	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation altering degron motif	0.7329
p.L815R	TCGA-D1-A16X	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.0556
p.T805A	TCGA-D8-A1XK	BRCA	TCGA	PHSST	DEG_SPOP_SBC_1	801:805	Mutation altering degron motif	0.7139
p.L800F	TCGA-DX-AB2E	SARC	TCGA	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.3056
p.P344H	TCGA-EE-A3AC	SKCM	TCGA	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.1944
p.P344H	DO37631	SKCM	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.1944
p.L793S	TCGA-F7-A624	HNSC	TCGA	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1111
p.P801S	TCGA-FR-A3R1	SKCM	TCGA	PHSST	DEG_SPOP_SBC_1	801:805	Mutation altering degron motif	0.6752
p.T660S	TCGA-NK-A5CX	LUSC	TCGA	DSGNPST	DEG_SCF_TRCP1_1	666:672	Mutation rewiring degron network	0.1667
p.S811L	DO49795	BLCA	ICGC	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1667
p.S811L	DO47257	SKCM	ICGC	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1667
p.K806N	DO49983	CESC	ICGC	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.3056
p.S802L	DO223732	CESC	ICGC	PHSST	DEG_SPOP_SBC_1	801:805	Mutation altering degron motif	0.7667
p.G672V	DO10582	COAD	ICGC	DSGNPST	DEG_SCF_TRCP1_1	666:672	Mutation altering degron motif	0.7532
p.V810A	DO7962	COAD	ICGC	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1944
p.Q363H	DO229026	LICA	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.1111
p.G358C	DO229026	LICA	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.25
p.N809H	DO22959	LIHC	ICGC	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.V364I	DO23176	LINC	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.0833
p.V364I	NBsusSR	autonomic ganglia	COSMIC	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.0833
p.T351A	DO23753	LUAD	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation altering degron motif	0.7139
p.T339S	DO219211	LUSC	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.0556
p.V342M	DO228376	MALY	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.1389
p.S343F	DO46832	RECA	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.1667
p.P791S	DO38404	STAD	ICGC	PHSST	DEG_SPOP_SBC_1	801:805	Mutation blocking phosphorylation signal	0.5
p.G347V	DO42033	UCEC	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.2778
p.A660V	DO41644	UCEC	ICGC	DSGNPST	DEG_SCF_TRCP1_1	666:672	Mutation rewiring degron network	0.1667
p.P794H	SIDM00839	Colorectal Carcinoma	GDSC	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1389
p.P794H	ACH-000950	Colon/Colorectal Cancer	CCLE	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1389
p.P794H	LoVo	large intestine	COSMIC	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1389
p.V795I	ASH-3	thyroid	COSMIC	PHSST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZCCHC2

UniProt ID: Q9C0B9

Entrez ID: 54877

Protein name: Zinc finger CCHC domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZCCHC2 in