DegronMD

Uniprot ID: Q9C0B9

Source protein: Zinc finger CCHC domain-containing protein 2

Source gene: ZCCHC2

Class: DEG_SCF_TRCP1_1

Location: 666:672

E3 ligase: BTRC

DEGRON score: 0.9606

ASA_SCORE: 78.9429

COIL: 0.9321

CONS_SCORE: 0.3403

DSS_SCORE: 0.7009

HELIX: 0.037

FCONS_SCORE: 0.9372

RIG_SCORE: 0.563

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T672A	TCGA-91-6831	LUAD	TCGA	DSGNPST	DEG_SCF_TRCP1_1	0.6028
p.G668V	TCGA-AP-A1DK	UCEC	TCGA	DSGNPST	DEG_SCF_TRCP1_1	0.7532
p.T660S	TCGA-NK-A5CX	LUSC	TCGA	DSGNPST	DEG_SCF_TRCP1_1	0.1667
p.G672V	DO10582	COAD	ICGC	DSGNPST	DEG_SCF_TRCP1_1	0.7532
p.A660V	DO41644	UCEC	ICGC	DSGNPST	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0B9	Zinc finger CCHC domain-containing protein 2	DEG_SCF_TRCP1_1	666:672	DSGNPST	BTRC	0.9606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons