DegronMD

Uniprot ID: Q9C0B9

Source protein: Zinc finger CCHC domain-containing protein 2

Source gene: ZCCHC2

Class: DEG_SPOP_SBC_1

Location: 801:805

E3 ligase: SPOP

DEGRON score: 0.9964

ASA_SCORE: 80.8

COIL: 0.936

CONS_SCORE: 0.3311

DSS_SCORE: 0.4133

HELIX: 0.0254

FCONS_SCORE: 0.9293

RIG_SCORE: 0.6541

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R814G	TCGA-A5-A0GP	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	0.0833
p.T805N	TCGA-AJ-A3EK	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	0.7055
p.L815R	TCGA-D1-A16X	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	0.0556
p.T805A	TCGA-D8-A1XK	BRCA	TCGA	PHSST	DEG_SPOP_SBC_1	0.7139
p.L800F	TCGA-DX-AB2E	SARC	TCGA	PHSST	DEG_SPOP_SBC_1	0.3056
p.L793S	TCGA-F7-A624	HNSC	TCGA	PHSST	DEG_SPOP_SBC_1	0.1111
p.P801S	TCGA-FR-A3R1	SKCM	TCGA	PHSST	DEG_SPOP_SBC_1	0.6752
p.S811L	DO49795	BLCA	ICGC	PHSST	DEG_SPOP_SBC_1	0.1667
p.S811L	DO47257	SKCM	ICGC	PHSST	DEG_SPOP_SBC_1	0.1667
p.K806N	DO49983	CESC	ICGC	PHSST	DEG_SPOP_SBC_1	0.3056
p.S802L	DO223732	CESC	ICGC	PHSST	DEG_SPOP_SBC_1	0.7667
p.V810A	DO7962	COAD	ICGC	PHSST	DEG_SPOP_SBC_1	0.1944
p.N809H	DO22959	LIHC	ICGC	PHSST	DEG_SPOP_SBC_1	0.2222
p.P791S	DO38404	STAD	ICGC	PHSST	DEG_SPOP_SBC_1	0.5
p.P794H	SIDM00839	Colorectal Carcinoma	GDSC	PHSST	DEG_SPOP_SBC_1	0.1389
p.P794H	ACH-000950	Colon/Colorectal Cancer	CCLE	PHSST	DEG_SPOP_SBC_1	0.1389
p.P794H	LoVo	large_intestine	COSMIC	PHSST	DEG_SPOP_SBC_1	0.1389
p.V795I	ASH-3	thyroid	COSMIC	PHSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68D10	Protein SPT2 homolog	DEG_SPOP_SBC_1	315:319	PHSST	SPOP	0.9783	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	54:58	PHSST	SPOP	0.9327	More...
Q9C0B9	Zinc finger CCHC domain-containing protein 2	DEG_SPOP_SBC_1	801:805	PHSST	SPOP	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons