DegronMD - Q68D10(SPTY2D1)

FUNCTION: Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubM... View more >>

GO - Biological processes (BP): histone exchange [GO:0043486]; nucleosome assembly [GO:0006334]; regulation of chromatin assembly [GO:0010847]; regulation of transcription, DNA-templated [GO:0006355]

GO - Molecular function (MF): DNA binding [GO:0003677]; histone binding [GO:0042393]; RNA polymerase I core binding [GO:0001042]

GO - Cellular component (CC): nucleolus [GO:0005730]; nucleoplasm [GO:0005654]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Degron hit	Class	E3 ligase	Source protein	Location	Detail
ALSSS	DEG_SPOP_SBC_1	SPOP	Protein SPT2 homolog	276:280	More..
PHSST	DEG_SPOP_SBC_1	SPOP	Protein SPT2 homolog	315:319	More..
PGSSS	DEG_SPOP_SBC_1	SPOP	Protein SPT2 homolog	371:375	More..
PASSS	DEG_SPOP_SBC_1	SPOP	Protein SPT2 homolog	438:442	More..

Showing 1 to 4 of 4 entries

Previous1Next

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S278C	TCGA-DK-AA75	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.8652
p.S278C	DO219012	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.8652
p.P438F	DO220893	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7897
p.A276D	DO229037	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7793
p.P371L	TCGA-HU-8602	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.7582
p.P371L	DO47829	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.7582
p.P438L	DO220893	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7582
p.P438L	SIDM00166	Other Solid Cancers	GDSC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7582
p.P438L	ACH-000302	Endometrial/Uterine Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7582
p.S318C	DO23130	LINC	ICGC	PHSST	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7541
p.A276T	TCGA-AG-3892	READ	TCGA	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.A276T	TCGA-D5-6928	COAD	TCGA	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.A276T	DO7776	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.A276T	DO36394	READ	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.T319I	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PHSST	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7078
p.T319I	ACH-000816	Lung Cancer	CCLE	PHSST	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7078
p.T319I	ACH-000916	Lung Cancer	CCLE	PHSST	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7078
p.T319I	NCI-H1573	lung	COSMIC	PHSST	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7078
p.P438S	DO220893	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.6752
p.A439T	DO234169	ESAD	ICGC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.6028

Showing 1 to 20 of 65 entries

Previous1 2 3 4Next

No resistance data available for this Degron.

Kaplan plot for SPTY2D1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPTY2D1

UniProt ID: Q68D10

Entrez ID: 144108

Protein name: Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

No resistance data available for this Degron.

Kaplan plot for SPTY2D1 in