DegronMD - Q68D10(SPTY2D1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T384I	TCGA-19-5956	GBM	TCGA	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.0833
p.T384I	DO13863	GBM	ICGC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.0833
p.A312T	TCGA-32-2616	GBM	TCGA	PHSST	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.A312T	DO13462	GBM	ICGC	PHSST	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.25
p.A276T	TCGA-AG-3892	READ	TCGA	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.A276T	TCGA-D5-6928	COAD	TCGA	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.A276T	DO7776	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.A276T	DO36394	READ	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.A363T	TCGA-AG-A014	READ	TCGA	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1111
p.A363T	DO36860	READ	ICGC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1111
p.A329T	TCGA-AX-A0J1	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.0556
p.A329T	DO41199	UCEC	ICGC	PHSST	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.0556
p.R287M	TCGA-B5-A11E	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.R287M	DO41644	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.K289R	TCGA-BR-7851	STAD	TCGA	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation blocking ubiquitination signal	0.5278
p.K289R	DO38711	STAD	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation blocking ubiquitination signal	0.5278
p.K289R	SIDM01612	Endometrial Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation blocking ubiquitination signal	0.5278
p.S278C	TCGA-DK-AA75	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.8652
p.S278C	DO219012	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.8652
p.R287W	TCGA-DM-A1HA	COAD	TCGA	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.R287W	DO8754	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.G385V	TCGA-DM-A1HB	COAD	TCGA	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.0556
p.K314E	TCGA-E6-A1LX	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.3056
p.K314E	DO41020	UCEC	ICGC	PHSST	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.3056
p.D305N	TCGA-EO-A3AZ	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.0556
p.D305N	DO50078	UCEC	ICGC	PHSST	DEG_SPOP_SBC_1	315:319	Mutation rewiring degron network	0.0556
p.P371L	TCGA-HU-8602	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.7582
p.P371L	DO47829	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.7582
p.Q381H	TCGA-OR-A5JA	ACC	TCGA	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1667
p.A439T	DO234169	ESAD	ICGC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.6028
p.R447Q	DO234285	ESAD	ICGC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1944
p.S377L	DO223116	ESCA	ICGC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.2778
p.A290V	DO222631	ESCA	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.L275I	DO228542	GACA	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.3056
p.T384K	DO229037	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.0833
p.A276D	DO229037	LICA	ICGC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7793
p.S318C	DO23130	LINC	ICGC	PHSST	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7541
p.S376N	DO231132	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.3056
p.P438L	DO220893	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7582
p.P438L	SIDM00166	Other Solid Cancers	GDSC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7582
p.P438L	ACH-000302	Endometrial/Uterine Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7582
p.P438F	DO220893	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.7897
p.P438S	DO220893	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation altering degron motif	0.6752
p.N361K	DO232224	PBCA	ICGC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.0556
p.P435R	SIDM00630	Breast Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.25
p.P435R	SIDM00672	Hepatocellular Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.25
p.P435R	SIDM00773	Non-Cancerous	GDSC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.25
p.P435R	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.25
p.P435R	SIDM00971	Breast Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.25
p.P435R	SIDM00774	Breast Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.25
p.A363S	SIDM00731	Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1111
p.A363S	ACH-000399	Lung Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1111
p.A363S	NCI-H2196	lung	COSMIC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1111
p.S282P	SIDM00438	B-Lymphoblastic Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.S282P	ACH-002275	Leukemia	CCLE	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.S282P	MN-60	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.S376I	SIDM00685	Glioblastoma	GDSC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.3056
p.S376I	ACH-000819	Brain Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.3056
p.S376I	LN-18	central nervous system	COSMIC	PGSSS	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.3056
p.T319I	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PHSST	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7078
p.T319I	ACH-000816	Lung Cancer	CCLE	PHSST	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7078
p.T319I	ACH-000916	Lung Cancer	CCLE	PHSST	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7078
p.T319I	NCI-H1573	lung	COSMIC	PHSST	DEG_SPOP_SBC_1	315:319	Mutation altering degron motif	0.7078
p.P448R	SIDM01343	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1667
p.P448R	ACH-000764	Gastric Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	438:442	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPTY2D1

UniProt ID: Q68D10

Entrez ID: 144108

Protein name: Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPTY2D1 in