DegronMD

Uniprot ID: Q9C0B9

Source protein: Zinc finger CCHC domain-containing protein 2

Source gene: ZCCHC2

Class: LIG_APCC_ABBAyCdc20_2

Location: 349:355

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8285

ASA_SCORE: 86.3429

COIL: 0.4724

CONS_SCORE: 0.5003

DSS_SCORE: 0.3163

HELIX: 0.1699

FCONS_SCORE: 1.3086

RIG_SCORE: 0.8322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R349Q	TCGA-B5-A11E	UCEC	TCGA	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R349Q	DO41644	UCEC	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.7329
p.P344H	TCGA-EE-A3AC	SKCM	TCGA	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P344H	DO37631	SKCM	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q363H	DO229026	LICA	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G358C	DO229026	LICA	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.25
p.V364I	DO23176	LINC	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V364I	NBsusSR	autonomic_ganglia	COSMIC	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.0833
p.T351A	DO23753	LUAD	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.7139
p.T339S	DO219211	LUSC	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V342M	DO228376	MALY	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S343F	DO46832	RECA	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G347V	DO42033	UCEC	ICGC	REAVHIE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0B9	Zinc finger CCHC domain-containing protein 2	LIG_APCC_ABBAyCdc20_2	349:355	REAVHIE	APC,CDC20,FZR1	0.8285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons