DegronMD

Uniprot ID: Q6UXF1

Source protein: Transmembrane protein 108

Source gene: TMEM108

Class: DEG_SPOP_SBC_1

Location: 123:127

E3 ligase: SPOP

DEGRON score: 0.9883

ASA_SCORE: 80.94

COIL: 0.9516

CONS_SCORE: 0.342

DSS_SCORE: 0.7632

HELIX: 0.015

FCONS_SCORE: 1.0336

RIG_SCORE: 0.6207

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G135R	TCGA-43-5668	LUSC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.1111
p.G135R	DO233624	GACA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1111
p.G135R	DO26608	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1111
p.E130Q	TCGA-A8-A0A7	BRCA	TCGA	ATTSS	DEG_SPOP_SBC_1	0.25
p.E130Q	DO5936	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.25
p.S126F	TCGA-EE-A2MJ	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	0.7982
p.S126F	DO38099	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	0.7982
p.A118T	DO230333	COCA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1944
p.G116W	DO233259	GACA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.S126T	DO224605	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.6005
p.R134Q	DO220902	MELA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.T115I	SIDM00525	Osteosarcoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.1111
p.T115I	ACH-000359	Bone Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.1111
p.T115I	MG-63	bone	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1111
p.A123E	SIDM00590	Oral Cavity Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.7701
p.A123E	ACH-000472	Head and Neck Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.7701
p.A123E	HSC-2	upper_aerodigestive_tract	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.7701
p.S114C	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ATTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28715	DNA excision repair protein ERCC-5	DEG_SPOP_SBC_1	1143:1147	ATTSS	SPOP	0.9952	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	353:357	ATTSS	SPOP	0.857	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1261:1265	ATTSS	SPOP	0.9691	More...
P78364	Polyhomeotic-like protein 1	DEG_SPOP_SBC_1	609:613	ATTSS	SPOP	0.9204	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	826:830	ATTSS	SPOP	0.9894	More...
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	1210:1214	ATTSS	SPOP	0.6255	More...
Q6PIW4	Fidgetin-like protein 1	DEG_SPOP_SBC_1	531:535	ATTSS	SPOP	0.5474	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	123:127	ATTSS	SPOP	0.9883	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7254:7258	ATTSS	SPOP	0.9689	More...
Q8NBF1	Zinc finger protein GLIS1	DEG_SPOP_SBC_1	433:437	ATTSS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	508:512	ATTSS	SPOP	0.9959	More...
Q92537	Sushi domain-containing protein 6	DEG_SPOP_SBC_1	255:259	ATTSS	SPOP	0.9991	More...
Q96HC4	PDZ and LIM domain protein 5	DEG_SPOP_SBC_1	155:159	ATTSS	SPOP	0.9493	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	366:370	ATTSS	SPOP	0.9751	More...
Q9UPP5	AP2-interacting clathrin-endocytosis protein	DEG_SPOP_SBC_1	742:746	ATTSS	SPOP	0.8709	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2121:2125	ATTSS	SPOP	0.9126	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	261:265	ATTSS	SPOP	0.9965	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1415:1419	ATTSS	SPOP	0.9991	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1281:1285	ATTSS	SPOP	0.9971	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	476:480	ATTSS	SPOP	0.674	More...
A6NGY3	Uncharacterized protein C5orf52	DEG_SPOP_SBC_1	25:29	ATTSS	SPOP	0.8442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTSS

Degron related mutations and impact score

Drug responses associated with TMEM108 mutations

All proteins holding degron of ATTSS