DegronMD - Q6PIW4(FIGNL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R538H	TCGA-A5-A0G2	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.25
p.R538H	DO41235	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.25
p.N228H	TCGA-AA-3510	COAD	TCGA	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7423
p.N228H	DO7783	COAD	ICGC	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7423
p.S230I	TCGA-AP-A059	UCEC	TCGA	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.3056
p.S230I	TCGA-AP-A059	UCEC	TCGA	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.2778
p.S230I	DO41361	UCEC	ICGC	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.3056
p.S230I	DO41361	UCEC	ICGC	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.2778
p.K521T	TCGA-AX-A05Z	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation substituting flanking lysine	0.1667
p.K521T	DO40884	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation substituting flanking lysine	0.1667
p.V541L	TCGA-AX-A1CF	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1667
p.V541L	DO43795	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1667
p.F221L	TCGA-B5-A0JR	UCEC	TCGA	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2222
p.F221L	DO41791	UCEC	ICGC	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2222
p.A531S	TCGA-B5-A3FA	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation altering degron motif	0.7588
p.A531S	DO52402	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation altering degron motif	0.7588
p.V240E	TCGA-BR-8682	STAD	TCGA	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.2222
p.V240E	DO47737	STAD	ICGC	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.2222
p.E523K	TCGA-DK-A2I2	BLCA	TCGA	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1111
p.E523K	DO708	BLCA	ICGC	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1111
p.K521N	TCGA-DU-6392	LGG	TCGA	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation substituting flanking lysine	0.1667
p.K521N	DO22237	LGG	ICGC	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation substituting flanking lysine	0.1667
p.T545K	DO229031	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.0556
p.P219L	DO222747	MELA	ICGC	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.1667
p.S231C	DO229146	NKTL	ICGC	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2778
p.S231C	DO229146	NKTL	ICGC	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.3056
p.D537G	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.2778
p.D537G	ACH-002301	Lymphoma	CCLE	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.2778
p.D537G	RF-48	stomach	COSMIC	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.2778
p.G237A	SIDM00481	Ovarian Carcinoma	GDSC	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.1111
p.G237A	SIDM00481	Ovarian Carcinoma	GDSC	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.3056
p.G237A	ACH-000116	Ovarian Cancer	CCLE	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.1111
p.G237A	ACH-000116	Ovarian Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.3056
p.G237A	OAW-28	ovary	COSMIC	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.1111
p.G237A	OAW-28	ovary	COSMIC	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.3056
p.N239I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.0556
p.N239I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.25
p.N239I	ACH-000904	Lung Cancer	CCLE	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.0556
p.N239I	ACH-000904	Lung Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.25
p.N239I	ACH-001362	Lung Cancer	CCLE	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.0556
p.N239I	ACH-001362	Lung Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.25
p.N239I	NCI-H1770	lung	COSMIC	KKENH	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.0556
p.N239I	NCI-H1770	lung	COSMIC	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.25
p.S243C	SIDM00836	Colorectal Carcinoma	GDSC	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.1389
p.S243C	ACH-000820	Colon/Colorectal Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.1389
p.S243C	SW403	large intestine	COSMIC	AKENI	DEG_APCC_KENBOX_2	232:236	Mutation rewiring degron network	0.1389
p.R538C	Sarc9371	bone	COSMIC	ATTSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.25

Kaplan plot for FIGNL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FIGNL1

UniProt ID: Q6PIW4

Entrez ID: 63979

Protein name: Fidgetin-like protein 1 (EC 3.6.4.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FIGNL1 in