DegronMD

Uniprot ID: Q6PIW4

Source protein: Fidgetin-like protein 1

Source gene: FIGNL1

Class: DEG_APCC_KENBOX_2

Location: 225:229

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9057

ASA_SCORE: 114.1

COIL: 0.8168

CONS_SCORE: 0.2188

DSS_SCORE: 0.391

HELIX: 0.1246

FCONS_SCORE: 1.0242

RIG_SCORE: 0.7458

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N228H	TCGA-AA-3510	COAD	TCGA	KKENH	DEG_APCC_KENBOX_2	0.7423
p.N228H	DO7783	COAD	ICGC	KKENH	DEG_APCC_KENBOX_2	0.7423
p.S230I	TCGA-AP-A059	UCEC	TCGA	KKENH	DEG_APCC_KENBOX_2	0.3056
p.S230I	DO41361	UCEC	ICGC	KKENH	DEG_APCC_KENBOX_2	0.3056
p.F221L	TCGA-B5-A0JR	UCEC	TCGA	KKENH	DEG_APCC_KENBOX_2	0.2222
p.F221L	DO41791	UCEC	ICGC	KKENH	DEG_APCC_KENBOX_2	0.2222
p.P219L	DO222747	MELA	ICGC	KKENH	DEG_APCC_KENBOX_2	0.1667
p.S231C	DO229146	NKTL	ICGC	KKENH	DEG_APCC_KENBOX_2	0.2778
p.G237A	SIDM00481	Ovarian Carcinoma	GDSC	KKENH	DEG_APCC_KENBOX_2	0.1111
p.G237A	ACH-000116	Ovarian Cancer	CCLE	KKENH	DEG_APCC_KENBOX_2	0.1111
p.G237A	OAW-28	ovary	COSMIC	KKENH	DEG_APCC_KENBOX_2	0.1111
p.N239I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	KKENH	DEG_APCC_KENBOX_2	0.0556
p.N239I	ACH-000904	Lung Cancer	CCLE	KKENH	DEG_APCC_KENBOX_2	0.0556
p.N239I	ACH-001362	Lung Cancer	CCLE	KKENH	DEG_APCC_KENBOX_2	0.0556
p.N239I	NCI-H1770	lung	COSMIC	KKENH	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PIW4	Fidgetin-like protein 1	DEG_APCC_KENBOX_2	225:229	KKENH	APC,CDC20,FZR1	0.9057	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons