DegronMD

Uniprot ID: Q6PIW4

Source protein: Fidgetin-like protein 1

Source gene: FIGNL1

Class: DEG_SPOP_SBC_1

Location: 531:535

E3 ligase: SPOP

DEGRON score: 0.5474

ASA_SCORE: 58.12

COIL: 0.9138

CONS_SCORE: 0.586

DSS_SCORE: 0.283

HELIX: 0.0518

FCONS_SCORE: 0.7415

RIG_SCORE: 0.7062

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R538H	TCGA-A5-A0G2	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.25
p.R538H	DO41235	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.25
p.K521T	TCGA-AX-A05Z	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.1667
p.K521T	DO40884	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1667
p.V541L	TCGA-AX-A1CF	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.1667
p.V541L	DO43795	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1667
p.A531S	TCGA-B5-A3FA	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.7588
p.A531S	DO52402	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.7588
p.E523K	TCGA-DK-A2I2	BLCA	TCGA	ATTSS	DEG_SPOP_SBC_1	0.1111
p.E523K	DO708	BLCA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1111
p.K521N	TCGA-DU-6392	LGG	TCGA	ATTSS	DEG_SPOP_SBC_1	0.1667
p.K521N	DO22237	LGG	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1667
p.T545K	DO229031	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.D537G	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.2778
p.D537G	ACH-002301	Lymphoma	CCLE	ATTSS	DEG_SPOP_SBC_1	0.2778
p.D537G	RF-48	stomach	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.2778
p.R538C	Sarc9371	bone	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28715	DNA excision repair protein ERCC-5	DEG_SPOP_SBC_1	1143:1147	ATTSS	SPOP	0.9952	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	353:357	ATTSS	SPOP	0.857	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1261:1265	ATTSS	SPOP	0.9691	More...
P78364	Polyhomeotic-like protein 1	DEG_SPOP_SBC_1	609:613	ATTSS	SPOP	0.9204	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	826:830	ATTSS	SPOP	0.9894	More...
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	1210:1214	ATTSS	SPOP	0.6255	More...
Q6PIW4	Fidgetin-like protein 1	DEG_SPOP_SBC_1	531:535	ATTSS	SPOP	0.5474	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	123:127	ATTSS	SPOP	0.9883	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7254:7258	ATTSS	SPOP	0.9689	More...
Q8NBF1	Zinc finger protein GLIS1	DEG_SPOP_SBC_1	433:437	ATTSS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	508:512	ATTSS	SPOP	0.9959	More...
Q92537	Sushi domain-containing protein 6	DEG_SPOP_SBC_1	255:259	ATTSS	SPOP	0.9991	More...
Q96HC4	PDZ and LIM domain protein 5	DEG_SPOP_SBC_1	155:159	ATTSS	SPOP	0.9493	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	366:370	ATTSS	SPOP	0.9751	More...
Q9UPP5	AP2-interacting clathrin-endocytosis protein	DEG_SPOP_SBC_1	742:746	ATTSS	SPOP	0.8709	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2121:2125	ATTSS	SPOP	0.9126	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	261:265	ATTSS	SPOP	0.9965	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1415:1419	ATTSS	SPOP	0.9991	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1281:1285	ATTSS	SPOP	0.9971	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	476:480	ATTSS	SPOP	0.674	More...
A6NGY3	Uncharacterized protein C5orf52	DEG_SPOP_SBC_1	25:29	ATTSS	SPOP	0.8442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTSS

Degron related mutations and impact score

Drug responses associated with FIGNL1 mutations

All proteins holding degron of ATTSS