DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
ATTSS
Uniprot ID:
Q58EX2
Source protein:
Protein sidekick-2
Source gene:
SDK2
Class:
DEG_SPOP_SBC_1
Location:
1210:1214
E3 ligase:
SPOP
DEGRON score:
0.6255
ASA_SCORE:
50.8
COIL:
0.5922
CONS_SCORE:
0.6007
DSS_SCORE:
0.3743
HELIX:
0.0136
FCONS_SCORE:
1.0371
RIG_SCORE:
0.7467
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G1202S
TCGA-A6-6781
COAD
TCGA
ATTSS
DEG_SPOP_SBC_1
0.1111
p.G1202S
DO8447
COAD
ICGC
ATTSS
DEG_SPOP_SBC_1
0.1111
p.S1215N
TCGA-EO-A3KX
UCEC
TCGA
ATTSS
DEG_SPOP_SBC_1
0.3056
p.S1215N
DO219774
UCEC
ICGC
ATTSS
DEG_SPOP_SBC_1
0.3056
p.W1220R
TCGA-G2-A3IB
BLCA
TCGA
ATTSS
DEG_SPOP_SBC_1
0.1667
p.W1220R
DO512
BLCA
ICGC
ATTSS
DEG_SPOP_SBC_1
0.1667
p.P1224L
DO234324
ESAD
ICGC
ATTSS
DEG_SPOP_SBC_1
0.0556
p.L1209M
DO229031
LICA
ICGC
ATTSS
DEG_SPOP_SBC_1
0.3056
p.P1203T
DO229009
LICA
ICGC
ATTSS
DEG_SPOP_SBC_1
0.1389
p.S1221R
DO46374
OV
ICGC
ATTSS
DEG_SPOP_SBC_1
0.5833
p.G1202D
SIDM02059
Colorectal Carcinoma
GDSC
ATTSS
DEG_SPOP_SBC_1
0.1111
p.E1222K
SIDM00982
Glioblastoma
GDSC
ATTSS
DEG_SPOP_SBC_1
0.1111
p.E1222K
ACH-000323
Brain Cancer
CCLE
ATTSS
DEG_SPOP_SBC_1
0.1111
p.E1222K
42-MG-BA
central_nervous_system
COSMIC
ATTSS
DEG_SPOP_SBC_1
0.1111
Drug responses associated with SDK2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ATTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P28715
DNA excision repair protein ERCC-5
DEG_SPOP_SBC_1
1143:1147
ATTSS
SPOP
0.9952
More...
P43694
Transcription factor GATA-4
DEG_SPOP_SBC_1
353:357
ATTSS
SPOP
0.857
More...
P49790
Nuclear pore complex protein Nup153
DEG_SPOP_SBC_1
1261:1265
ATTSS
SPOP
0.9691
More...
P78364
Polyhomeotic-like protein 1
DEG_SPOP_SBC_1
609:613
ATTSS
SPOP
0.9204
More...
Q2M3C7
A-kinase anchor protein SPHKAP
DEG_SPOP_SBC_1
826:830
ATTSS
SPOP
0.9894
More...
Q58EX2
Protein sidekick-2
DEG_SPOP_SBC_1
1210:1214
ATTSS
SPOP
0.6255
More...
Q6PIW4
Fidgetin-like protein 1
DEG_SPOP_SBC_1
531:535
ATTSS
SPOP
0.5474
More...
Q6UXF1
Transmembrane protein 108
DEG_SPOP_SBC_1
123:127
ATTSS
SPOP
0.9883
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
7254:7258
ATTSS
SPOP
0.9689
More...
Q8NBF1
Zinc finger protein GLIS1
DEG_SPOP_SBC_1
433:437
ATTSS
SPOP
0.9971
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
508:512
ATTSS
SPOP
0.9959
More...
Q92537
Sushi domain-containing protein 6
DEG_SPOP_SBC_1
255:259
ATTSS
SPOP
0.9991
More...
Q96HC4
PDZ and LIM domain protein 5
DEG_SPOP_SBC_1
155:159
ATTSS
SPOP
0.9493
More...
Q9ULI3
Protein HEG homolog 1
DEG_SPOP_SBC_1
366:370
ATTSS
SPOP
0.9751
More...
Q9UPP5
AP2-interacting clathrin-endocytosis protein
DEG_SPOP_SBC_1
742:746
ATTSS
SPOP
0.8709
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
2121:2125
ATTSS
SPOP
0.9126
More...
Q8IX06
Putative exonuclease GOR
DEG_SPOP_SBC_1
261:265
ATTSS
SPOP
0.9965
More...
E2RYF6
Mucin-22
DEG_SPOP_SBC_1
1415:1419
ATTSS
SPOP
0.9991
More...
Q2KHR3
Glutamine and serine-rich protein 1
DEG_SPOP_SBC_1
1281:1285
ATTSS
SPOP
0.9971
More...
Q5BKX6
Solute carrier family 45 member 4
DEG_SPOP_SBC_1
476:480
ATTSS
SPOP
0.674
More...
A6NGY3
Uncharacterized protein C5orf52
DEG_SPOP_SBC_1
25:29
ATTSS
SPOP
0.8442
More...