DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 508:512

E3 ligase: SPOP

DEGRON score: 0.9959

ASA_SCORE: 81.7

COIL: 0.8714

CONS_SCORE: 0

DSS_SCORE: 0.5303

HELIX: 0.0156

FCONS_SCORE: 0

RIG_SCORE: 0.6549

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E522K	TCGA-AF-5654	READ	TCGA	ATTSS	DEG_SPOP_SBC_1	0.0556
p.E522K	DO36647	READ	ICGC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.S518L	TCGA-AX-A1C8	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.1667
p.S518L	DO43338	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1667
p.K515Q	TCGA-CA-6717	COAD	TCGA	ATTSS	DEG_SPOP_SBC_1	0.3611
p.K515Q	DO8264	COAD	ICGC	ATTSS	DEG_SPOP_SBC_1	0.3611
p.A508T	TCGA-EE-A182	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	0.7139
p.A508T	DO37814	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	0.7139
p.S502C	DO233034	GACA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.6111
p.T513P	DO233634	GACA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.3056
p.T513I	DO220881	MELA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.3056
p.A516T	DO232761	PBCA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.2222
p.R507K	DO229446	SKCA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.3056
p.T509A	DO229446	SKCA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.6028
p.G501R	SIDM01104	Melanoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.G501R	SIDM01015	Chronic Myelogenous Leukemia	GDSC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.G501R	SIDM00082	Melanoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.G501R	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.G501R	SK-MEL-31	skin	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.G501R	SK-MEL-2	skin	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.E522A	SIDM00795	Melanoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.E522A	ACH-000219	Skin Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.0556
p.E522A	ACH-002001	Skin Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.0556
p.E522A	ACH-002002	Skin Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.0556
p.E522A	ACH-002003	Skin Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.0556
p.E522A	A375	skin	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.A508E	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.7701
p.A508E	ACH-000809	Esophageal Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.7701
p.A508E	KYSE-410	oesophagus	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.7701
p.L506P	SIDM00523	Small Cell Lung Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.2778
p.L506P	DMS-53	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.2778
p.G501E	ACH-001610	Brain Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28715	DNA excision repair protein ERCC-5	DEG_SPOP_SBC_1	1143:1147	ATTSS	SPOP	0.9952	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	353:357	ATTSS	SPOP	0.857	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1261:1265	ATTSS	SPOP	0.9691	More...
P78364	Polyhomeotic-like protein 1	DEG_SPOP_SBC_1	609:613	ATTSS	SPOP	0.9204	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	826:830	ATTSS	SPOP	0.9894	More...
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	1210:1214	ATTSS	SPOP	0.6255	More...
Q6PIW4	Fidgetin-like protein 1	DEG_SPOP_SBC_1	531:535	ATTSS	SPOP	0.5474	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	123:127	ATTSS	SPOP	0.9883	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7254:7258	ATTSS	SPOP	0.9689	More...
Q8NBF1	Zinc finger protein GLIS1	DEG_SPOP_SBC_1	433:437	ATTSS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	508:512	ATTSS	SPOP	0.9959	More...
Q92537	Sushi domain-containing protein 6	DEG_SPOP_SBC_1	255:259	ATTSS	SPOP	0.9991	More...
Q96HC4	PDZ and LIM domain protein 5	DEG_SPOP_SBC_1	155:159	ATTSS	SPOP	0.9493	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	366:370	ATTSS	SPOP	0.9751	More...
Q9UPP5	AP2-interacting clathrin-endocytosis protein	DEG_SPOP_SBC_1	742:746	ATTSS	SPOP	0.8709	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2121:2125	ATTSS	SPOP	0.9126	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	261:265	ATTSS	SPOP	0.9965	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1415:1419	ATTSS	SPOP	0.9991	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1281:1285	ATTSS	SPOP	0.9971	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	476:480	ATTSS	SPOP	0.674	More...
A6NGY3	Uncharacterized protein C5orf52	DEG_SPOP_SBC_1	25:29	ATTSS	SPOP	0.8442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of ATTSS