DegronMD - P78364(PHC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M719L	TCGA-23-1117	OV	TCGA	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation rewiring degron network	0.1944
p.H603R	TCGA-36-2539	OV	TCGA	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1667
p.V729M	TCGA-AX-A1CE	UCEC	TCGA	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation altering degron motif	0.7208
p.V729M	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation altering degron motif	0.7208
p.V729M	ACH-002059	Leukemia	CCLE	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation altering degron motif	0.7208
p.V729M	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation altering degron motif	0.7208
p.K730T	TCGA-B5-A1MR	UCEC	TCGA	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation altering degron motif	0.6195
p.H736R	TCGA-DU-6392	LGG	TCGA	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation rewiring degron network	0.2222
p.G720A	TCGA-V5-A7RB	ESCA	TCGA	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation rewiring degron network	0.2222
p.M719I	TCGA-ZG-A9LN	PRAD	TCGA	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation rewiring degron network	0.1944
p.K599E	DO227935	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.0556
p.K599M	DO14164	HNSC	ICGC	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.0556
p.A602T	DO232761	PBCA	ICGC	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1389
p.I737L	SIDM02072	Colorectal Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation rewiring degron network	0.1944
p.A704T	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation altering degron motif	0.6028
p.A704T	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation altering degron motif	0.6028
p.A704T	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation altering degron motif	0.6028
p.A704T	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation altering degron motif	0.6028
p.A704T	SIDM00528	Breast Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation altering degron motif	0.6028
p.A704T	SIDM01325	Pancreatic Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation altering degron motif	0.6028
p.Q618E	SIDM00680	Colorectal Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1944
p.Q618E	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1944
p.Q618E	ACH-000596	Lung Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1944
p.Q618E	ACH-000957	Colon/Colorectal Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1944
p.Q618E	LS-180	large intestine	COSMIC	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1944
p.Q618E	LCLC-97TM1	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1944
p.A617V	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.2222
p.A617V	ACH-000596	Lung Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.2222
p.A617V	LCLC-97TM1	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.2222
p.P708A	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation rewiring degron network	0.2778
p.P708A	ACH-000528	Lung Cancer	CCLE	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation rewiring degron network	0.2778
p.P708A	ABC-1	lung	COSMIC	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation rewiring degron network	0.2778
p.P708R	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation rewiring degron network	0.2778
p.P708R	ACH-000528	Lung Cancer	CCLE	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation rewiring degron network	0.2778
p.P708R	ABC-1	lung	COSMIC	VALTPAPS	DEG_SCF_FBW7_1	699:706	Mutation rewiring degron network	0.2778
p.P614S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.3056
p.P614S	ACH-002222	Leukemia	CCLE	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.3056
p.P614S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.3056
p.V619I	ACH-000949	Gastric Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	609:613	Mutation rewiring degron network	0.1667
p.G727W	C-33-A	cervix	COSMIC	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation altering degron motif	0.7825
p.P736R	LS-123	large intestine	COSMIC	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation rewiring degron network	0.2222
p.E717D	LNCaP-Clone-FGC	prostate	COSMIC	PPQAIVKPQ	DEG_SIAH_1	724:732	Mutation rewiring degron network	0.1389

Kaplan plot for PHC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHC1

UniProt ID: P78364

Entrez ID: 1911

Protein name: Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHC1 in