DegronMD

Uniprot ID: P78364

Source protein: Polyhomeotic-like protein 1

Source gene: PHC1

Class: DEG_SCF_FBW7_1

Location: 699:706

E3 ligase: FBXW7

DEGRON score: 0.7758

ASA_SCORE: 92.775

COIL: 0.9468

CONS_SCORE: 0.4582

DSS_SCORE: 0.5479

HELIX: 0.0256

FCONS_SCORE: 1.1107

RIG_SCORE: 0.6779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A704T	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	0.6028
p.A704T	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	0.6028
p.A704T	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	0.6028
p.A704T	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	0.6028
p.A704T	SIDM00528	Breast Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	0.6028
p.A704T	SIDM01325	Pancreatic Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	0.6028
p.P708A	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	0.2778
p.P708A	ACH-000528	Lung Cancer	CCLE	VALTPAPS	DEG_SCF_FBW7_1	0.2778
p.P708A	ABC-1	lung	COSMIC	VALTPAPS	DEG_SCF_FBW7_1	0.2778
p.P708R	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	VALTPAPS	DEG_SCF_FBW7_1	0.2778
p.P708R	ACH-000528	Lung Cancer	CCLE	VALTPAPS	DEG_SCF_FBW7_1	0.2778
p.P708R	ABC-1	lung	COSMIC	VALTPAPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78364	Polyhomeotic-like protein 1	DEG_SCF_FBW7_1	699:706	VALTPAPS	FBXW7	0.7758	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons