DegronMD

Uniprot ID: P78364

Source protein: Polyhomeotic-like protein 1

Source gene: PHC1

Class: DEG_SIAH_1

Location: 724:732

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.7654

ASA_SCORE: 88.3444

COIL: 0.8654

CONS_SCORE: 0.6694

DSS_SCORE: 0.439

HELIX: 0.0417

FCONS_SCORE: 1.0873

RIG_SCORE: 0.7592

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M719L	TCGA-23-1117	OV	TCGA	PPQAIVKPQ	DEG_SIAH_1	0.1944
p.V729M	TCGA-AX-A1CE	UCEC	TCGA	PPQAIVKPQ	DEG_SIAH_1	0.7208
p.V729M	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.7208
p.V729M	ACH-002059	Leukemia	CCLE	PPQAIVKPQ	DEG_SIAH_1	0.7208
p.V729M	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PPQAIVKPQ	DEG_SIAH_1	0.7208
p.K730T	TCGA-B5-A1MR	UCEC	TCGA	PPQAIVKPQ	DEG_SIAH_1	0.6195
p.H736R	TCGA-DU-6392	LGG	TCGA	PPQAIVKPQ	DEG_SIAH_1	0.2222
p.G720A	TCGA-V5-A7RB	ESCA	TCGA	PPQAIVKPQ	DEG_SIAH_1	0.2222
p.M719I	TCGA-ZG-A9LN	PRAD	TCGA	PPQAIVKPQ	DEG_SIAH_1	0.1944
p.I737L	SIDM02072	Colorectal Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.1944
p.G727W	C-33-A	cervix	COSMIC	PPQAIVKPQ	DEG_SIAH_1	0.7825
p.P736R	LS-123	large_intestine	COSMIC	PPQAIVKPQ	DEG_SIAH_1	0.2222
p.E717D	LNCaP-Clone-FGC	prostate	COSMIC	PPQAIVKPQ	DEG_SIAH_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons