DegronMD

Uniprot ID: Q8NDX5

Source protein: Polyhomeotic-like protein 3

Source gene: PHC3

Class: DEG_SIAH_1

Location: 692:700

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.757

ASA_SCORE: 87.0556

COIL: 0.8791

CONS_SCORE: 0.5695

DSS_SCORE: 0.3812

HELIX: 0.0861

FCONS_SCORE: 0.9071

RIG_SCORE: 0.7453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S695C	TCGA-66-2734	LUSC	TCGA	PPQAIVKPQ	DEG_SIAH_1	0.7541
p.S695C	DO26430	LUSC	ICGC	PPQAIVKPQ	DEG_SIAH_1	0.7541
p.I700V	TCGA-CR-6492	HNSC	TCGA	PPQAIVKPQ	DEG_SIAH_1	0.7076
p.I700V	DO14170	HNSC	ICGC	PPQAIVKPQ	DEG_SIAH_1	0.7076
p.S695I	TCGA-DF-A2KU	UCEC	TCGA	PPQAIVKPQ	DEG_SIAH_1	0.7341
p.S695I	DO223286	UCEC	ICGC	PPQAIVKPQ	DEG_SIAH_1	0.7341
p.Q706K	DO228974	LICA	ICGC	PPQAIVKPQ	DEG_SIAH_1	0.1667
p.P705A	DO228985	LICA	ICGC	PPQAIVKPQ	DEG_SIAH_1	0.1944
p.V706I	DO41847	UCEC	ICGC	PPQAIVKPQ	DEG_SIAH_1	0.1667
p.S695G	SIDM00993	Plasma Cell Myeloma	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.6993
p.S695G	SIDM00373	Endometrial Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.6993
p.S695G	SIDM00614	Hepatocellular Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.6993
p.S695G	SIDM01242	Melanoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.6993
p.S695G	SIDM00869	Non-Cancerous	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.6993
p.S695G	SIDM00383	Gastric Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.6993
p.S695G	SIDM00239	Kidney Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.6993
p.S695G	SIDM00045	Gastric Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.6993
p.S695G	SIDM01526	Mesothelioma	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.6993
p.S695G	SIDM01464	Pancreatic Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	0.6993

DegronMD: protein-targeted degradation, mutation and drug response to degrons