DegronMD

Uniprot ID: Q96HC4

Source protein: PDZ and LIM domain protein 5

Source gene: PDLIM5

Class: DEG_SPOP_SBC_1

Location: 155:159

E3 ligase: SPOP

DEGRON score: 0.9493

ASA_SCORE: 75.88

COIL: 0.8776

CONS_SCORE: 0.4368

DSS_SCORE: 0.5119

HELIX: 0.0978

FCONS_SCORE: 1.0317

RIG_SCORE: 0.6048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S154G	TCGA-85-7697	LUSC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.3056
p.S151R	DO225081	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.2222
p.S151R	DO52559	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.2222
p.P165L	DO8103	COAD	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1667
p.S148G	DO27053	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.P164S	DO228138	PBCA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1944
p.A155V	SIDM00450	Acute Myeloid Leukemia	GDSC	ATTSS	DEG_SPOP_SBC_1	0.5825
p.A155V	SIDM01570	Ovarian Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.5825
p.A155V	ACH-000218	Leukemia	CCLE	ATTSS	DEG_SPOP_SBC_1	0.5825
p.A155V	ACH-000324	Ovarian Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.5825
p.A155V	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.5825
p.T151I	SIDM00129	Melanoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.2222
p.W168C	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.0833
p.W168C	ACH-000852	Lung Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.0833
p.W168C	NCI-H1435	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.0833
p.H160Y	SIDM01445	Gastric Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.3056
p.H160Y	ACH-000736	Gastric Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.3056
p.R169C	ACH-000172	Rhabdoid	CCLE	ATTSS	DEG_SPOP_SBC_1	0.0556
p.W162C	NCI-H1435	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.25
p.C154F	SCH	stomach	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.3056
p.L163P	NCI-H810	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.2222
p.W148C	NCI-H1435	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.Q156E	MDA-MB-453	breast	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28715	DNA excision repair protein ERCC-5	DEG_SPOP_SBC_1	1143:1147	ATTSS	SPOP	0.9952	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	353:357	ATTSS	SPOP	0.857	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1261:1265	ATTSS	SPOP	0.9691	More...
P78364	Polyhomeotic-like protein 1	DEG_SPOP_SBC_1	609:613	ATTSS	SPOP	0.9204	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	826:830	ATTSS	SPOP	0.9894	More...
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	1210:1214	ATTSS	SPOP	0.6255	More...
Q6PIW4	Fidgetin-like protein 1	DEG_SPOP_SBC_1	531:535	ATTSS	SPOP	0.5474	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	123:127	ATTSS	SPOP	0.9883	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7254:7258	ATTSS	SPOP	0.9689	More...
Q8NBF1	Zinc finger protein GLIS1	DEG_SPOP_SBC_1	433:437	ATTSS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	508:512	ATTSS	SPOP	0.9959	More...
Q92537	Sushi domain-containing protein 6	DEG_SPOP_SBC_1	255:259	ATTSS	SPOP	0.9991	More...
Q96HC4	PDZ and LIM domain protein 5	DEG_SPOP_SBC_1	155:159	ATTSS	SPOP	0.9493	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	366:370	ATTSS	SPOP	0.9751	More...
Q9UPP5	AP2-interacting clathrin-endocytosis protein	DEG_SPOP_SBC_1	742:746	ATTSS	SPOP	0.8709	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2121:2125	ATTSS	SPOP	0.9126	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	261:265	ATTSS	SPOP	0.9965	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1415:1419	ATTSS	SPOP	0.9991	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1281:1285	ATTSS	SPOP	0.9971	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	476:480	ATTSS	SPOP	0.674	More...
A6NGY3	Uncharacterized protein C5orf52	DEG_SPOP_SBC_1	25:29	ATTSS	SPOP	0.8442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTSS

Degron related mutations and impact score

Drug responses associated with PDLIM5 mutations

All proteins holding degron of ATTSS