DegronMD - Q96HC4(PDLIM5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S154G	TCGA-85-7697	LUSC	TCGA	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.3056
p.S151R	DO225081	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.2222
p.S151R	DO52559	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.2222
p.P165L	DO8103	COAD	ICGC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1667
p.S148G	DO27053	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1389
p.P164S	DO228138	PBCA	ICGC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1944
p.A155V	SIDM00450	Acute Myeloid Leukemia	GDSC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.5825
p.A155V	SIDM01570	Ovarian Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.5825
p.A155V	ACH-000218	Leukemia	CCLE	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.5825
p.A155V	ACH-000324	Ovarian Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.5825
p.A155V	PL-21	haematopoietic and lymphoid tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.5825
p.T151I	SIDM00129	Melanoma	GDSC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.2222
p.W168C	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0833
p.W168C	ACH-000852	Lung Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0833
p.W168C	NCI-H1435	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0833
p.H160Y	SIDM01445	Gastric Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.3056
p.H160Y	ACH-000736	Gastric Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.3056
p.R169C	ACH-000172	Rhabdoid	CCLE	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0556
p.W162C	NCI-H1435	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.25
p.C154F	SCH	stomach	COSMIC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.3056
p.L163P	NCI-H810	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.2222
p.W148C	NCI-H1435	lung	COSMIC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1389
p.Q156E	MDA-MB-453	breast	COSMIC	ATTSS	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.6744

Kaplan plot for PDLIM5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDLIM5

UniProt ID: Q96HC4

Entrez ID: 10611

Protein name: PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDLIM5 in