DegronMD

Uniprot ID: P43694

Source protein: Transcription factor GATA-4

Source gene: GATA4

Class: DEG_SPOP_SBC_1

Location: 353:357

E3 ligase: SPOP

DEGRON score: 0.857

ASA_SCORE: 85.3

COIL: 0.9392

CONS_SCORE: 0.3241

DSS_SCORE: 0.6879

HELIX: 0.043

FCONS_SCORE: 0.9434

RIG_SCORE: 0.5605

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E359K	TCGA-98-8020	LUSC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.2778
p.R362C	TCGA-AP-A0LM	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.1944
p.R362C	ACH-000979	Prostate Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.1944
p.R362C	DU-145	prostate	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1944
p.T355S	TCGA-AX-A2HJ	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.6005
p.T355S	TCGA-BR-4256	STAD	TCGA	ATTSS	DEG_SPOP_SBC_1	0.6005
p.T366M	TCGA-CK-4950	COAD	TCGA	ATTSS	DEG_SPOP_SBC_1	0.0833
p.T366M	TCGA-ND-A4WC	UCS	TCGA	ATTSS	DEG_SPOP_SBC_1	0.0833
p.T366M	ACH-000686	Liver Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.0833
p.A343S	TCGA-DK-A3X2	BLCA	TCGA	ATTSS	DEG_SPOP_SBC_1	0.0556
p.S344I	TCGA-P6-A5OG	ACC	TCGA	ATTSS	DEG_SPOP_SBC_1	0.0833
p.A344S	DO617	BLCA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.0833
p.T367M	DO8506	COAD	ICGC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.T367M	DO234185	ESAD	ICGC	ATTSS	DEG_SPOP_SBC_1	0.0556
p.R363C	DO234350	ESAD	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1667
p.R363C	DO43306	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1667
p.R363C	SIDM00120	Prostate Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.1667
p.R363C	DU-145	prostate	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1667
p.A344T	DO233156	GACA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.0833
p.T356S	DO233205	GACA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.7116
p.T356S	DO38743	STAD	ICGC	ATTSS	DEG_SPOP_SBC_1	0.7116
p.T356S	DO42105	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.7116
p.M362I	DO229045	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.1944
p.S352R	DO229051	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	0.3056
p.E360K	DO45428	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	0.25
p.S357R	SIDM00064	Hepatocellular Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.7427
p.S357R	HLE	liver	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.7427
p.G346S	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.G346S	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1389
p.S357T	SIDM00500	Colorectal Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	0.6005
p.S356R	ACH-000393	Liver Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.7427
p.S356R	ACH-001089	Liver Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.7427
p.S356R	HLE	liver	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.7427
p.S357N	ACH-001610	Brain Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	0.7069
p.G345S	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.1111
p.R361C	DU-145	prostate	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.2222
p.S355R	HLE	liver	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.7427
p.G344S	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28715	DNA excision repair protein ERCC-5	DEG_SPOP_SBC_1	1143:1147	ATTSS	SPOP	0.9952	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	353:357	ATTSS	SPOP	0.857	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1261:1265	ATTSS	SPOP	0.9691	More...
P78364	Polyhomeotic-like protein 1	DEG_SPOP_SBC_1	609:613	ATTSS	SPOP	0.9204	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	826:830	ATTSS	SPOP	0.9894	More...
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	1210:1214	ATTSS	SPOP	0.6255	More...
Q6PIW4	Fidgetin-like protein 1	DEG_SPOP_SBC_1	531:535	ATTSS	SPOP	0.5474	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	123:127	ATTSS	SPOP	0.9883	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7254:7258	ATTSS	SPOP	0.9689	More...
Q8NBF1	Zinc finger protein GLIS1	DEG_SPOP_SBC_1	433:437	ATTSS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	508:512	ATTSS	SPOP	0.9959	More...
Q92537	Sushi domain-containing protein 6	DEG_SPOP_SBC_1	255:259	ATTSS	SPOP	0.9991	More...
Q96HC4	PDZ and LIM domain protein 5	DEG_SPOP_SBC_1	155:159	ATTSS	SPOP	0.9493	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	366:370	ATTSS	SPOP	0.9751	More...
Q9UPP5	AP2-interacting clathrin-endocytosis protein	DEG_SPOP_SBC_1	742:746	ATTSS	SPOP	0.8709	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2121:2125	ATTSS	SPOP	0.9126	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	261:265	ATTSS	SPOP	0.9965	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1415:1419	ATTSS	SPOP	0.9991	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1281:1285	ATTSS	SPOP	0.9971	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	476:480	ATTSS	SPOP	0.674	More...
A6NGY3	Uncharacterized protein C5orf52	DEG_SPOP_SBC_1	25:29	ATTSS	SPOP	0.8442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTSS

Degron related mutations and impact score

Drug responses associated with GATA4 mutations

All proteins holding degron of ATTSS