DegronMD

Uniprot ID: Q6PIW4

Source protein: Fidgetin-like protein 1

Source gene: FIGNL1

Class: DEG_APCC_KENBOX_2

Location: 232:236

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.54

ASA_SCORE: 92.54

COIL: 0.6612

CONS_SCORE: 0.2166

DSS_SCORE: 0.3426

HELIX: 0.2984

FCONS_SCORE: 1.0015

RIG_SCORE: 0.7401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S230I	TCGA-AP-A059	UCEC	TCGA	AKENI	DEG_APCC_KENBOX_2	0.2778
p.S230I	DO41361	UCEC	ICGC	AKENI	DEG_APCC_KENBOX_2	0.2778
p.V240E	TCGA-BR-8682	STAD	TCGA	AKENI	DEG_APCC_KENBOX_2	0.2222
p.V240E	DO47737	STAD	ICGC	AKENI	DEG_APCC_KENBOX_2	0.2222
p.S231C	DO229146	NKTL	ICGC	AKENI	DEG_APCC_KENBOX_2	0.3056
p.G237A	SIDM00481	Ovarian Carcinoma	GDSC	AKENI	DEG_APCC_KENBOX_2	0.3056
p.G237A	ACH-000116	Ovarian Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	0.3056
p.G237A	OAW-28	ovary	COSMIC	AKENI	DEG_APCC_KENBOX_2	0.3056
p.N239I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	AKENI	DEG_APCC_KENBOX_2	0.25
p.N239I	ACH-000904	Lung Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	0.25
p.N239I	ACH-001362	Lung Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	0.25
p.N239I	NCI-H1770	lung	COSMIC	AKENI	DEG_APCC_KENBOX_2	0.25
p.S243C	SIDM00836	Colorectal Carcinoma	GDSC	AKENI	DEG_APCC_KENBOX_2	0.1389
p.S243C	ACH-000820	Colon/Colorectal Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	0.1389
p.S243C	SW403	large_intestine	COSMIC	AKENI	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03188	Centromere protein C	DEG_APCC_KENBOX_2	783:787	AKENI	APC,CDC20,FZR1	0.9965	More...
Q1MSJ5	Centrosome and spindle pole-associated protein 1	DEG_APCC_KENBOX_2	87:91	AKENI	APC,CDC20,FZR1	0.9612	More...
Q6PIW4	Fidgetin-like protein 1	DEG_APCC_KENBOX_2	232:236	AKENI	APC,CDC20,FZR1	0.54	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons