DegronMD - Q1MSJ5(CSPP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K746N	TCGA-06-5416	GBM	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.1944
p.K746N	TCGA-AA-A010	COAD	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.1944
p.K746N	TCGA-AX-A0J0	UCEC	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.1944
p.K746N	DO10880	GBM	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.1944
p.K746N	DO41133	UCEC	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.1944
p.R767W	TCGA-A2-A0EQ	BRCA	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.0556
p.R767W	TCGA-A6-6653	COAD	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.0556
p.R767W	DO4773	BRCA	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.0556
p.R767W	DO10373	COAD	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.0556
p.R767W	DO233687	GACA	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.0556
p.R756I	TCGA-A5-A0G2	UCEC	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation altering degron motif	0.8102
p.R756I	DO41235	UCEC	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation altering degron motif	0.8102
p.E750Q	TCGA-A6-5660	COAD	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.3056
p.E750Q	DO7972	COAD	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.3056
p.I84F	TCGA-BG-A222	UCEC	TCGA	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.25
p.I84F	DO42977	UCEC	ICGC	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.25
p.T98P	TCGA-E6-A1LX	UCEC	TCGA	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.1389
p.T98P	DO41020	UCEC	ICGC	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.1389
p.A760V	TCGA-EO-A3AZ	UCEC	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.25
p.A760V	DO50078	UCEC	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.25
p.R99S	TCGA-ER-A19B	SKCM	TCGA	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.1111
p.R99S	DO47491	SKCM	ICGC	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.1111
p.S85Y	TCGA-ER-A19N	SKCM	TCGA	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation blocking phosphorylation signal	0.7222
p.S85Y	DO37452	SKCM	ICGC	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation blocking phosphorylation signal	0.7222
p.S85Y	SIDM01307	Colorectal Carcinoma	GDSC	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation blocking phosphorylation signal	0.7222
p.A87T	TCGA-R5-A7ZR	STAD	TCGA	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation altering degron motif	0.6028
p.A87T	DO222343	STAD	ICGC	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation altering degron motif	0.6028
p.R754Q	DO222864	COCA	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation altering degron motif	0.7329
p.E765K	DO50736	LICA	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation blocking ubiquitination signal	0.5556
p.E750A	DO220876	MELA	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.3056
p.K88N	DO232224	PBCA	ICGC	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation altering degron motif	0.6918
p.K763N	SIDM00193	Colorectal Carcinoma	GDSC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.1667
p.K763N	ACH-000991	Colon/Colorectal Cancer	CCLE	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.1667
p.K763N	SNU-81	large intestine	COSMIC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.1667
p.I743N	SIDM01133	Other Solid Cancers	GDSC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.1111
p.I743N	NCI-H835	lung	COSMIC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.1111
p.S101A	ACH-001401	Adrenal Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation blocking phosphorylation signal	0.5
p.S101A	SW13	adrenal gland	COSMIC	AKENI	DEG_APCC_KENBOX_2	87:91	Mutation blocking phosphorylation signal	0.5
p.R750C	LS-180	large intestine	COSMIC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.3056
p.S742L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.0833
p.R750H	CW-2	large intestine	COSMIC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	751:757	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSPP1

UniProt ID: Q1MSJ5

Entrez ID: 79848

Protein name: Centrosome and spindle pole-associated protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSPP1 in