DegronMD

Uniprot ID: Q1MSJ5

Source protein: Centrosome and spindle pole-associated protein 1

Source gene: CSPP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 751:757

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9939

ASA_SCORE: 89.0714

COIL: 0.9163

CONS_SCORE: 0.463

DSS_SCORE: 0.6007

HELIX: 0.0466

FCONS_SCORE: 1.0326

RIG_SCORE: 0.6423

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K746N	TCGA-06-5416	GBM	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K746N	TCGA-AA-A010	COAD	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K746N	TCGA-AX-A0J0	UCEC	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K746N	DO10880	GBM	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K746N	DO41133	UCEC	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R767W	TCGA-A2-A0EQ	BRCA	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R767W	TCGA-A6-6653	COAD	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R767W	DO4773	BRCA	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R767W	DO10373	COAD	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R767W	DO233687	GACA	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R756I	TCGA-A5-A0G2	UCEC	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R756I	DO41235	UCEC	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.8102
p.E750Q	TCGA-A6-5660	COAD	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E750Q	DO7972	COAD	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.A760V	TCGA-EO-A3AZ	UCEC	TCGA	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.25
p.A760V	DO50078	UCEC	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.25
p.R754Q	DO222864	COCA	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.7329
p.E765K	DO50736	LICA	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.5556
p.E750A	DO220876	MELA	ICGC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K763N	SIDM00193	Colorectal Carcinoma	GDSC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K763N	ACH-000991	Colon/Colorectal Cancer	CCLE	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K763N	SNU-81	large_intestine	COSMIC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.I743N	SIDM01133	Other Solid Cancers	GDSC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.I743N	NCI-H835	lung	COSMIC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R750C	LS-180	large_intestine	COSMIC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S742L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R750H	CW-2	large_intestine	COSMIC	RGNVFGE	LIG_APCC_ABBAyCdc20_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RGNVFGE

Degron related mutations and impact score

Drug responses associated with CSPP1 mutations

All proteins holding degron of RGNVFGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q1MSJ5	Centrosome and spindle pole-associated protein 1	LIG_APCC_ABBAyCdc20_2	751:757	RGNVFGE	APC,CDC20,FZR1	0.9939	More...