DegronMD

Uniprot ID: Q1MSJ5

Source protein: Centrosome and spindle pole-associated protein 1

Source gene: CSPP1

Class: DEG_APCC_KENBOX_2

Location: 87:91

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9612

ASA_SCORE: 90.94

COIL: 0.7564

CONS_SCORE: 0.3583

DSS_SCORE: 0.5496

HELIX: 0.1722

FCONS_SCORE: 0.9724

RIG_SCORE: 0.72

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I84F	TCGA-BG-A222	UCEC	TCGA	AKENI	DEG_APCC_KENBOX_2	0.25
p.I84F	DO42977	UCEC	ICGC	AKENI	DEG_APCC_KENBOX_2	0.25
p.T98P	TCGA-E6-A1LX	UCEC	TCGA	AKENI	DEG_APCC_KENBOX_2	0.1389
p.T98P	DO41020	UCEC	ICGC	AKENI	DEG_APCC_KENBOX_2	0.1389
p.R99S	TCGA-ER-A19B	SKCM	TCGA	AKENI	DEG_APCC_KENBOX_2	0.1111
p.R99S	DO47491	SKCM	ICGC	AKENI	DEG_APCC_KENBOX_2	0.1111
p.S85Y	TCGA-ER-A19N	SKCM	TCGA	AKENI	DEG_APCC_KENBOX_2	0.7222
p.S85Y	DO37452	SKCM	ICGC	AKENI	DEG_APCC_KENBOX_2	0.7222
p.S85Y	SIDM01307	Colorectal Carcinoma	GDSC	AKENI	DEG_APCC_KENBOX_2	0.7222
p.A87T	TCGA-R5-A7ZR	STAD	TCGA	AKENI	DEG_APCC_KENBOX_2	0.6028
p.A87T	DO222343	STAD	ICGC	AKENI	DEG_APCC_KENBOX_2	0.6028
p.K88N	DO232224	PBCA	ICGC	AKENI	DEG_APCC_KENBOX_2	0.6918
p.S101A	ACH-001401	Adrenal Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	0.5
p.S101A	SW13	adrenal_gland	COSMIC	AKENI	DEG_APCC_KENBOX_2	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03188	Centromere protein C	DEG_APCC_KENBOX_2	783:787	AKENI	APC,CDC20,FZR1	0.9965	More...
Q1MSJ5	Centrosome and spindle pole-associated protein 1	DEG_APCC_KENBOX_2	87:91	AKENI	APC,CDC20,FZR1	0.9612	More...
Q6PIW4	Fidgetin-like protein 1	DEG_APCC_KENBOX_2	232:236	AKENI	APC,CDC20,FZR1	0.54	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons