DegronMD - Q03188(CENPC)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P666Q	TCGA-09-2044	OV	TCGA	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation rewiring degron network	0.2222
p.P666Q	TCGA-09-2044	OV	TCGA	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation rewiring degron network	0.1667
p.P666Q	DO28923	OV	ICGC	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation rewiring degron network	0.2222
p.P666Q	DO28923	OV	ICGC	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation rewiring degron network	0.1667
p.T662K	TCGA-09-2044	OV	TCGA	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation rewiring degron network	0.1111
p.T662K	TCGA-09-2044	OV	TCGA	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation rewiring degron network	0.0556
p.T662K	TCGA-F1-6177	STAD	TCGA	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation rewiring degron network	0.1111
p.T662K	TCGA-F1-6177	STAD	TCGA	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation rewiring degron network	0.0556
p.T662K	DO28923	OV	ICGC	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation rewiring degron network	0.1111
p.T662K	DO28923	OV	ICGC	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation rewiring degron network	0.0556
p.T662K	DO38727	STAD	ICGC	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation rewiring degron network	0.1111
p.T662K	DO38727	STAD	ICGC	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation rewiring degron network	0.0556
p.S778L	TCGA-AN-A046	BRCA	TCGA	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.1944
p.S778L	DO1285	BRCA	ICGC	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.1944
p.S778L	DO222798	COCA	ICGC	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.1944
p.S778L	SIDM00905	Cervical Carcinoma	GDSC	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.1944
p.S778L	ACH-001334	Cervical Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.1944
p.S778L	ACH-001335	Cervical Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.1944
p.S778L	C-4-I	cervix	COSMIC	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.1944
p.R744H	TCGA-AP-A051	UCEC	TCGA	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.7133
p.R744H	DO42673	UCEC	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.7133
p.P774A	TCGA-B2-5641	KIRC	TCGA	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.0833
p.P774A	DO19603	KIRC	ICGC	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.0833
p.R755Q	TCGA-B5-A11E	UCEC	TCGA	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1667
p.R755Q	TCGA-EY-A1GI	UCEC	TCGA	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1667
p.R755Q	DO41644	UCEC	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1667
p.R755Q	DO41211	UCEC	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1667
p.T743S	TCGA-BS-A0UJ	UCEC	TCGA	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.6005
p.T743S	DO42745	UCEC	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.6005
p.K793R	TCGA-EO-A22R	UCEC	TCGA	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation substituting flanking lysine	0.2778
p.K793R	DO42713	UCEC	ICGC	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation substituting flanking lysine	0.2778
p.K789Q	TCGA-EO-A22X	UCEC	TCGA	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.2778
p.K789Q	DO43907	UCEC	ICGC	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.2778
p.R739M	TCGA-GN-A265	SKCM	TCGA	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.2778
p.R739M	DO37491	SKCM	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.2778
p.N791S	DO228352	BRCA	ICGC	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.2222
p.N736D	DO228650	LICA	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.1944
p.P747H	DO229029	LICA	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation altering degron motif	0.6583
p.D775E	DO229027	LICA	ICGC	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.1111
p.T667K	DO229037	LICA	ICGC	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation rewiring degron network	0.25
p.T667K	DO229037	LICA	ICGC	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation rewiring degron network	0.1944
p.S773F	DO228014	SKCA	ICGC	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation blocking phosphorylation signal	0.5
p.S684N	SIDM00961	Ewing's Sarcoma	GDSC	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation blocking phosphorylation signal	0.5278
p.S684N	SIDM00961	Ewing's Sarcoma	GDSC	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation blocking phosphorylation signal	0.6111
p.S684N	CADO-ES1	bone	COSMIC	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation blocking phosphorylation signal	0.5278
p.S684N	CADO-ES1	bone	COSMIC	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation blocking phosphorylation signal	0.6111
p.C663S	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation rewiring degron network	0.1389
p.C663S	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation rewiring degron network	0.0833
p.C663S	ACH-000858	Lung Cancer	CCLE	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation rewiring degron network	0.1389
p.C663S	ACH-000858	Lung Cancer	CCLE	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation rewiring degron network	0.0833
p.C663S	KNS-62	lung	COSMIC	NLDSGE	DEG_Kelch_Keap1_1	670:675	Mutation rewiring degron network	0.1389
p.C663S	KNS-62	lung	COSMIC	DSGEHKT	DEG_SCF_TRCP1_1	672:678	Mutation rewiring degron network	0.0833
p.Q759E	SIDM00493	Other Solid Cancers	GDSC	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.0556
p.Q759E	SIDM00785	Acute Myeloid Leukemia	GDSC	KRTRLKPLE	DEG_APCC_DBOX_1	741:749	Mutation rewiring degron network	0.0556
p.N795D	SIDM00621	Ewing's Sarcoma	GDSC	AKENI	DEG_APCC_KENBOX_2	783:787	Mutation rewiring degron network	0.1111

Kaplan plot for CENPC in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CENPC

UniProt ID: Q03188

Entrez ID: 1060

Protein name: Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CENPC in