DegronMD

Uniprot ID: Q03188

Source protein: Centromere protein C

Source gene: CENPC

Class: DEG_APCC_DBOX_1

Location: 741:749

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9938

ASA_SCORE: 103.8778

COIL: 0.798

CONS_SCORE: 0.6418

DSS_SCORE: 0.4556

HELIX: 0.0852

FCONS_SCORE: 1.0062

RIG_SCORE: 0.8171

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R744H	TCGA-AP-A051	UCEC	TCGA	KRTRLKPLE	DEG_APCC_DBOX_1	0.7133
p.R744H	DO42673	UCEC	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	0.7133
p.R755Q	TCGA-B5-A11E	UCEC	TCGA	KRTRLKPLE	DEG_APCC_DBOX_1	0.1667
p.R755Q	TCGA-EY-A1GI	UCEC	TCGA	KRTRLKPLE	DEG_APCC_DBOX_1	0.1667
p.R755Q	DO41644	UCEC	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	0.1667
p.R755Q	DO41211	UCEC	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	0.1667
p.T743S	TCGA-BS-A0UJ	UCEC	TCGA	KRTRLKPLE	DEG_APCC_DBOX_1	0.6005
p.T743S	DO42745	UCEC	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	0.6005
p.R739M	TCGA-GN-A265	SKCM	TCGA	KRTRLKPLE	DEG_APCC_DBOX_1	0.2778
p.R739M	DO37491	SKCM	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	0.2778
p.N736D	DO228650	LICA	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	0.1944
p.P747H	DO229029	LICA	ICGC	KRTRLKPLE	DEG_APCC_DBOX_1	0.6583
p.Q759E	SIDM00493	Other Solid Cancers	GDSC	KRTRLKPLE	DEG_APCC_DBOX_1	0.0556
p.Q759E	SIDM00785	Acute Myeloid Leukemia	GDSC	KRTRLKPLE	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03188	Centromere protein C	DEG_APCC_DBOX_1	741:749	KRTRLKPLE	APC,CDC20,FZR1	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons