DegronMD

Uniprot ID: Q03188

Source protein: Centromere protein C

Source gene: CENPC

Class: DEG_Kelch_Keap1_1

Location: 670:675

E3 ligase: KEAP1

DEGRON score: 0.9506

ASA_SCORE: 92.0333

COIL: 0.883

CONS_SCORE: 0.2696

DSS_SCORE: 0.5783

HELIX: 0.0915

FCONS_SCORE: 0.9794

RIG_SCORE: 0.6378

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P666Q	TCGA-09-2044	OV	TCGA	NLDSGE	DEG_Kelch_Keap1_1	0.2222
p.P666Q	DO28923	OV	ICGC	NLDSGE	DEG_Kelch_Keap1_1	0.2222
p.T662K	TCGA-09-2044	OV	TCGA	NLDSGE	DEG_Kelch_Keap1_1	0.1111
p.T662K	TCGA-F1-6177	STAD	TCGA	NLDSGE	DEG_Kelch_Keap1_1	0.1111
p.T662K	DO28923	OV	ICGC	NLDSGE	DEG_Kelch_Keap1_1	0.1111
p.T662K	DO38727	STAD	ICGC	NLDSGE	DEG_Kelch_Keap1_1	0.1111
p.T667K	DO229037	LICA	ICGC	NLDSGE	DEG_Kelch_Keap1_1	0.25
p.S684N	SIDM00961	Ewing's Sarcoma	GDSC	NLDSGE	DEG_Kelch_Keap1_1	0.5278
p.S684N	CADO-ES1	bone	COSMIC	NLDSGE	DEG_Kelch_Keap1_1	0.5278
p.C663S	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	NLDSGE	DEG_Kelch_Keap1_1	0.1389
p.C663S	ACH-000858	Lung Cancer	CCLE	NLDSGE	DEG_Kelch_Keap1_1	0.1389
p.C663S	KNS-62	lung	COSMIC	NLDSGE	DEG_Kelch_Keap1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03188	Centromere protein C	DEG_Kelch_Keap1_1	670:675	NLDSGE	KEAP1	0.9506	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons