DegronMD

Uniprot ID: Q03188

Source protein: Centromere protein C

Source gene: CENPC

Class: DEG_SCF_TRCP1_1

Location: 672:678

E3 ligase: BTRC

DEGRON score: 0.9698

ASA_SCORE: 98.6714

COIL: 0.8543

CONS_SCORE: 0.2728

DSS_SCORE: 0.636

HELIX: 0.0954

FCONS_SCORE: 0.979

RIG_SCORE: 0.6601

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P666Q	TCGA-09-2044	OV	TCGA	DSGEHKT	DEG_SCF_TRCP1_1	0.1667
p.P666Q	DO28923	OV	ICGC	DSGEHKT	DEG_SCF_TRCP1_1	0.1667
p.T662K	TCGA-09-2044	OV	TCGA	DSGEHKT	DEG_SCF_TRCP1_1	0.0556
p.T662K	TCGA-F1-6177	STAD	TCGA	DSGEHKT	DEG_SCF_TRCP1_1	0.0556
p.T662K	DO28923	OV	ICGC	DSGEHKT	DEG_SCF_TRCP1_1	0.0556
p.T662K	DO38727	STAD	ICGC	DSGEHKT	DEG_SCF_TRCP1_1	0.0556
p.T667K	DO229037	LICA	ICGC	DSGEHKT	DEG_SCF_TRCP1_1	0.1944
p.S684N	SIDM00961	Ewing's Sarcoma	GDSC	DSGEHKT	DEG_SCF_TRCP1_1	0.6111
p.S684N	CADO-ES1	bone	COSMIC	DSGEHKT	DEG_SCF_TRCP1_1	0.6111
p.C663S	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	DSGEHKT	DEG_SCF_TRCP1_1	0.0833
p.C663S	ACH-000858	Lung Cancer	CCLE	DSGEHKT	DEG_SCF_TRCP1_1	0.0833
p.C663S	KNS-62	lung	COSMIC	DSGEHKT	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03188	Centromere protein C	DEG_SCF_TRCP1_1	672:678	DSGEHKT	BTRC	0.9698	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons