DegronMD

Uniprot ID: Q03188

Source protein: Centromere protein C

Source gene: CENPC

Class: DEG_APCC_KENBOX_2

Location: 783:787

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9965

ASA_SCORE: 107.9

COIL: 0.8578

CONS_SCORE: 0.3808

DSS_SCORE: 0.5397

HELIX: 0.1366

FCONS_SCORE: 1.035

RIG_SCORE: 0.7211

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S778L	TCGA-AN-A046	BRCA	TCGA	AKENI	DEG_APCC_KENBOX_2	0.1944
p.S778L	DO1285	BRCA	ICGC	AKENI	DEG_APCC_KENBOX_2	0.1944
p.S778L	DO222798	COCA	ICGC	AKENI	DEG_APCC_KENBOX_2	0.1944
p.S778L	SIDM00905	Cervical Carcinoma	GDSC	AKENI	DEG_APCC_KENBOX_2	0.1944
p.S778L	ACH-001334	Cervical Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	0.1944
p.S778L	ACH-001335	Cervical Cancer	CCLE	AKENI	DEG_APCC_KENBOX_2	0.1944
p.S778L	C-4-I	cervix	COSMIC	AKENI	DEG_APCC_KENBOX_2	0.1944
p.P774A	TCGA-B2-5641	KIRC	TCGA	AKENI	DEG_APCC_KENBOX_2	0.0833
p.P774A	DO19603	KIRC	ICGC	AKENI	DEG_APCC_KENBOX_2	0.0833
p.K793R	TCGA-EO-A22R	UCEC	TCGA	AKENI	DEG_APCC_KENBOX_2	0.2778
p.K793R	DO42713	UCEC	ICGC	AKENI	DEG_APCC_KENBOX_2	0.2778
p.K789Q	TCGA-EO-A22X	UCEC	TCGA	AKENI	DEG_APCC_KENBOX_2	0.2778
p.K789Q	DO43907	UCEC	ICGC	AKENI	DEG_APCC_KENBOX_2	0.2778
p.N791S	DO228352	BRCA	ICGC	AKENI	DEG_APCC_KENBOX_2	0.2222
p.D775E	DO229027	LICA	ICGC	AKENI	DEG_APCC_KENBOX_2	0.1111
p.S773F	DO228014	SKCA	ICGC	AKENI	DEG_APCC_KENBOX_2	0.5
p.N795D	SIDM00621	Ewing's Sarcoma	GDSC	AKENI	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03188	Centromere protein C	DEG_APCC_KENBOX_2	783:787	AKENI	APC,CDC20,FZR1	0.9965	More...
Q1MSJ5	Centrosome and spindle pole-associated protein 1	DEG_APCC_KENBOX_2	87:91	AKENI	APC,CDC20,FZR1	0.9612	More...
Q6PIW4	Fidgetin-like protein 1	DEG_APCC_KENBOX_2	232:236	AKENI	APC,CDC20,FZR1	0.54	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons