DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AKENI
Uniprot ID:
Q03188
Source protein:
Centromere protein C
Source gene:
CENPC
Class:
DEG_APCC_KENBOX_2
Location:
783:787
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9965
ASA_SCORE:
107.9
COIL:
0.8578
CONS_SCORE:
0.3808
DSS_SCORE:
0.5397
HELIX:
0.1366
FCONS_SCORE:
1.035
RIG_SCORE:
0.7211
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S773F
DO228014
SKCA
ICGC
AKENI
DEG_APCC_KENBOX_2
0.5
p.K793R
TCGA-EO-A22R
UCEC
TCGA
AKENI
DEG_APCC_KENBOX_2
0.2778
p.K793R
DO42713
UCEC
ICGC
AKENI
DEG_APCC_KENBOX_2
0.2778
p.K789Q
TCGA-EO-A22X
UCEC
TCGA
AKENI
DEG_APCC_KENBOX_2
0.2778
p.K789Q
DO43907
UCEC
ICGC
AKENI
DEG_APCC_KENBOX_2
0.2778
p.N791S
DO228352
BRCA
ICGC
AKENI
DEG_APCC_KENBOX_2
0.2222
p.S778L
TCGA-AN-A046
BRCA
TCGA
AKENI
DEG_APCC_KENBOX_2
0.1944
p.S778L
DO1285
BRCA
ICGC
AKENI
DEG_APCC_KENBOX_2
0.1944
p.S778L
DO222798
COCA
ICGC
AKENI
DEG_APCC_KENBOX_2
0.1944
p.S778L
SIDM00905
Cervical Carcinoma
GDSC
AKENI
DEG_APCC_KENBOX_2
0.1944
p.S778L
ACH-001334
Cervical Cancer
CCLE
AKENI
DEG_APCC_KENBOX_2
0.1944
p.S778L
ACH-001335
Cervical Cancer
CCLE
AKENI
DEG_APCC_KENBOX_2
0.1944
p.S778L
C-4-I
cervix
COSMIC
AKENI
DEG_APCC_KENBOX_2
0.1944
p.D775E
DO229027
LICA
ICGC
AKENI
DEG_APCC_KENBOX_2
0.1111
p.N795D
SIDM00621
Ewing's Sarcoma
GDSC
AKENI
DEG_APCC_KENBOX_2
0.1111
p.P774A
TCGA-B2-5641
KIRC
TCGA
AKENI
DEG_APCC_KENBOX_2
0.0833
p.P774A
DO19603
KIRC
ICGC
AKENI
DEG_APCC_KENBOX_2
0.0833
Showing 1 to 17 of 17 entries
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Drug responses associated with CENPC mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of AKENI
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q03188
Centromere protein C
DEG_APCC_KENBOX_2
783:787
AKENI
APC,CDC20,FZR1
0.9965
More...
Q1MSJ5
Centrosome and spindle pole-associated protein 1
DEG_APCC_KENBOX_2
87:91
AKENI
APC,CDC20,FZR1
0.9612
More...
Q6PIW4
Fidgetin-like protein 1
DEG_APCC_KENBOX_2
232:236
AKENI
APC,CDC20,FZR1
0.54
More...
Showing 1 to 3 of 3 entries
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