DegronMD - Q6ZU67(BEND4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R451C	TCGA-2W-A8YY	CESC	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.719
p.R451C	DO223732	CESC	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.719
p.R451C	DO227609	COCA	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.719
p.R451C	DO32908	PACA	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.719
p.P296A	TCGA-44-5644	LUAD	TCGA	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.W293L	TCGA-55-7570	LUAD	TCGA	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1111
p.N255Y	TCGA-55-8506	LUAD	TCGA	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1111
p.L282R	TCGA-66-2734	LUSC	TCGA	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation altering degron motif	0.7316
p.A277T	TCGA-66-2754	LUSC	TCGA	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.0833
p.A277T	TCGA-66-2754	LUSC	TCGA	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222
p.E300K	TCGA-AA-A00N	COAD	TCGA	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1944
p.E300K	TCGA-EO-A3B0	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1944
p.K39M	TCGA-AD-6895	COAD	TCGA	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation substituting flanking lysine	0.3611
p.P455S	TCGA-B5-A11E	UCEC	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.5641
p.P455S	DO41644	UCEC	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.5641
p.V441M	TCGA-CD-A4MG	STAD	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.1111
p.S268L	TCGA-D3-A3MV	SKCM	TCGA	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7667
p.S268L	TCGA-EE-A3JD	SKCM	TCGA	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7667
p.S268L	TCGA-FR-A7UA	SKCM	TCGA	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7667
p.P265T	TCGA-DD-A11A	LIHC	TCGA	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7031
p.T459A	TCGA-DD-AAD6	LIHC	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2778
p.T459A	DO52224	LIHC	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2778
p.D280N	TCGA-DF-A2KU	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.S259L	TCGA-DR-A0ZM	CESC	TCGA	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2222
p.P263Q	TCGA-EE-A3AD	SKCM	TCGA	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7035
p.S306Y	TCGA-EO-A3B0	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	305:309	Mutation altering degron motif	0.6009
p.P452L	TCGA-ER-A19O	SKCM	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.6471
p.P452L	DO38063	SKCM	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.6471
p.V279L	TCGA-FR-A3R1	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2778
p.P265Q	TCGA-FR-A726	SKCM	TCGA	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7035
p.E449K	TCGA-FW-A3R5	SKCM	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.591
p.E449K	DO37406	SKCM	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.591
p.S295F	TCGA-FW-A3R5	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.0556
p.S295F	TCGA-FW-A3R5	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0556
p.S295F	TCGA-ZF-A9R7	BLCA	TCGA	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.0556
p.S295F	TCGA-ZF-A9R7	BLCA	TCGA	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0556
p.L282V	TCGA-MA-AA3Z	CESC	TCGA	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation altering degron motif	0.5654
p.E319K	TCGA-VR-AA7B	ESCA	TCGA	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0556
p.S440L	TCGA-W3-AA1R	SKCM	TCGA	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation blocking phosphorylation signal	0.5278
p.S291F	DO219064	BLCA	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1667
p.S291F	DO37406	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1667
p.L33P	DO225203	BRCA	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation substituting flanking lysine	0.1944
p.L278V	DO219722	CESC	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.0556
p.L278V	DO219722	CESC	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.S255L	DO6254	CESC	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1111
p.K35M	DO8938	COAD	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.1389
p.E296K	DO9876	COAD	ICGC	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.E296K	DO219773	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.G444V	DO230342	COCA	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.1944
p.P56L	DO227816	COCA	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.1667
p.S297F	DO50403	ESAD	ICGC	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1111
p.V132I	DO234404	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.25
p.V132I	DO34448	PACA	ICGC	AASSS	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.25
p.A139V	DO233762	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.0556
p.A118V	DO233843	GACA	ICGC	PSCTPATS	DEG_SCF_FBW7_1	102:109	Mutation rewiring degron network	0.0833
p.A118V	DO233843	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.1389
p.P60L	DO233867	GACA	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.0556
p.H284N	DO229015	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation altering degron motif	0.7423
p.P452H	DO229031	LICA	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.6583
p.P53T	DO229037	LICA	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.25
p.T280N	DO229008	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.P261T	DO22835	LIHC	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2778
p.P52S	DO231518	LINC	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.2778
p.W289L	DO25280	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222
p.P292A	DO25153	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1389
p.N262I	DO231204	LUSC	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.3056
p.L278R	DO26430	LUSC	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.0556
p.L278R	DO26430	LUSC	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.A273T	DO27612	LUSC	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1944
p.A273T	DO27612	LUSC	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1111
p.G256E	DO220877	MELA	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1389
p.S264L	DO220899	MELA	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7667
p.S264L	DO37727	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7667
p.S264L	DO50299	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7667
p.S264L	DO51253	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7667
p.S257C	DO222409	MELA	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1667
p.E268K	DO222595	MELA	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7022
p.P452S	DO222824	MELA	ICGC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.5641
p.P117S	DO51489	PACA	ICGC	PSCTPATS	DEG_SCF_FBW7_1	102:109	Mutation rewiring degron network	0.1111
p.P117S	DO51489	PACA	ICGC	AASSS	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.1111
p.P261L	DO219878	SKCA	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2778
p.G288S	DO218884	SKCA	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.P259Q	DO37707	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2222
p.P261Q	DO48665	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.2778
p.V275L	DO37991	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1389
p.V275L	DO37991	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1667
p.P60S	DO229163	THCA	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.0556
p.S302Y	DO219773	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.25
p.D276N	DO223286	UCEC	ICGC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1111
p.D276N	DO223286	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1944
p.E445K	SIDM01096	Colorectal Carcinoma	GDSC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2222
p.E445K	ACH-000400	Colon/Colorectal Cancer	CCLE	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2222
p.E445K	SK-CO-1	large intestine	COSMIC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2222
p.N255K	SIDM01261	Breast Carcinoma	GDSC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1111
p.N255K	ACH-002208	Breast Cancer	CCLE	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1111
p.N255K	YMB-1-E	breast	COSMIC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1111
p.T284A	SIDM00614	Hepatocellular Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation altering degron motif	0.7139
p.T284A	ACH-000848	Liver Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation altering degron motif	0.7139
p.T284A	JHH-7	liver	COSMIC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation altering degron motif	0.7139
p.A38D	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.2222
p.A38D	ACH-000893	Lung Cancer	CCLE	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.2222
p.G447S	SIDM00683	Prostate Carcinoma	GDSC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2778
p.G447S	ACH-000977	lymph node	CCLE	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2778
p.G447S	LNCaP-Clone-FGC	prostate	COSMIC	ERRPLDPVK	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2778
p.R40C	SIDM00217	Colorectal Carcinoma	GDSC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.2778
p.Q254R	SIDM01059	Melanoma	GDSC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.0833
p.Q254R	ACH-000915	Skin Cancer	CCLE	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.0833
p.Q254R	IPC-298	skin	COSMIC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.0833
p.H275Y	SIDM01498	Acute Myeloid Leukemia	GDSC	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1389
p.H275Y	SIDM01498	Acute Myeloid Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1667
p.H275Y	ACH-000487	Leukemia	CCLE	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation rewiring degron network	0.1389
p.H275Y	ACH-000487	Leukemia	CCLE	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1667
p.S32R	ACH-000693	Esophageal Cancer	CCLE	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.0556
p.E316G	ACH-000957	Colon/Colorectal Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1389
p.S130F	ACH-001061	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.3056
p.P102R	ACH-001402	Cervical Cancer	CCLE	PSCTPATS	DEG_SCF_FBW7_1	102:109	Mutation altering degron motif	0.7512
p.T264I	ACH-002005	Skin Cancer	CCLE	PTPNPS	DEG_SCF_FBW7_1	263:268	Mutation altering degron motif	0.7078
p.R36Q	JSC-1	haematopoietic and lymphoid tissue	COSMIC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.1667
p.R36Q	T-24	urinary tract	COSMIC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.1667
p.N126K	YMB-1-E	breast	COSMIC	AASSS	DEG_SPOP_SBC_1	125:129	Mutation altering degron motif	0.6918
p.G318S	LNCaP-Clone-FGC	prostate	COSMIC	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.0833
p.E316K	SK-CO-1	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1389
p.G57E	Sarc9371	bone	COSMIC	ERPTLVELP	DEG_APCC_DBOX_1	42:50	Mutation rewiring degron network	0.1389
p.T280A	JHH-7	liver	COSMIC	PLSTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.A115V	KM12	large intestine	COSMIC	PSCTPATS	DEG_SCF_FBW7_1	102:109	Mutation rewiring degron network	0.1667
p.A115V	KM12	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	125:129	Mutation rewiring degron network	0.0556
p.H93D	NCI-H748	lung	COSMIC	PSCTPATS	DEG_SCF_FBW7_1	102:109	Mutation rewiring degron network	0.0833
p.H93D	NCI-H748	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.25
p.I102L	HT55	large intestine	COSMIC	PSCTPATS	DEG_SCF_FBW7_1	102:109	Mutation altering degron motif	0.7174
p.Y301C	HT-115	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.2222
p.Q125R	IPC-298	skin	COSMIC	AASSS	DEG_SPOP_SBC_1	125:129	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BEND4

UniProt ID: Q6ZU67

Entrez ID: 389206

Protein name: BEN domain-containing protein 4 (Coiled-coil domain-containing protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BEND4 in