DegronMD

Uniprot ID: Q6ZU67

Source protein: BEN domain-containing protein 4

Source gene: BEND4

Class: DEG_SCF_FBW7_1

Location: 102:109

E3 ligase: FBXW7

DEGRON score: 0.9636

ASA_SCORE: 78.5125

COIL: 0.8851

CONS_SCORE: 0.5416

DSS_SCORE: 0.6745

HELIX: 0.0823

FCONS_SCORE: 1.059

RIG_SCORE: 0.5457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A118V	DO233843	GACA	ICGC	PSCTPATS	DEG_SCF_FBW7_1	0.0833
p.P117S	DO51489	PACA	ICGC	PSCTPATS	DEG_SCF_FBW7_1	0.1111
p.P102R	ACH-001402	Cervical Cancer	CCLE	PSCTPATS	DEG_SCF_FBW7_1	0.7512
p.A115V	KM12	large_intestine	COSMIC	PSCTPATS	DEG_SCF_FBW7_1	0.1667
p.H93D	NCI-H748	lung	COSMIC	PSCTPATS	DEG_SCF_FBW7_1	0.0833
p.I102L	HT55	large_intestine	COSMIC	PSCTPATS	DEG_SCF_FBW7_1	0.7174

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZU67	BEN domain-containing protein 4	DEG_SCF_FBW7_1	102:109	PSCTPATS	FBXW7	0.9636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons