DegronMD

Uniprot ID: Q6ZU67

Source protein: BEN domain-containing protein 4

Source gene: BEND4

Class: DEG_SCF_FBW7_1

Location: 263:268

E3 ligase: FBXW7

DEGRON score: 0.9653

ASA_SCORE: 85.3667

COIL: 0.9432

CONS_SCORE: 0.4699

DSS_SCORE: 0.4252

HELIX: 0.0367

FCONS_SCORE: 0.6586

RIG_SCORE: 0.6122

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N255Y	TCGA-55-8506	LUAD	TCGA	PTPNPS	DEG_SCF_FBW7_1	0.1111
p.A277T	TCGA-66-2754	LUSC	TCGA	PTPNPS	DEG_SCF_FBW7_1	0.0833
p.S268L	TCGA-D3-A3MV	SKCM	TCGA	PTPNPS	DEG_SCF_FBW7_1	0.7667
p.S268L	TCGA-EE-A3JD	SKCM	TCGA	PTPNPS	DEG_SCF_FBW7_1	0.7667
p.S268L	TCGA-FR-A7UA	SKCM	TCGA	PTPNPS	DEG_SCF_FBW7_1	0.7667
p.P265T	TCGA-DD-A11A	LIHC	TCGA	PTPNPS	DEG_SCF_FBW7_1	0.7031
p.S259L	TCGA-DR-A0ZM	CESC	TCGA	PTPNPS	DEG_SCF_FBW7_1	0.2222
p.P263Q	TCGA-EE-A3AD	SKCM	TCGA	PTPNPS	DEG_SCF_FBW7_1	0.7035
p.P265Q	TCGA-FR-A726	SKCM	TCGA	PTPNPS	DEG_SCF_FBW7_1	0.7035
p.L278V	DO219722	CESC	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.0556
p.S255L	DO6254	CESC	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.1111
p.P261T	DO22835	LIHC	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.2778
p.N262I	DO231204	LUSC	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.3056
p.L278R	DO26430	LUSC	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.0556
p.A273T	DO27612	LUSC	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.1944
p.G256E	DO220877	MELA	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.1389
p.S264L	DO220899	MELA	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.7667
p.S264L	DO37727	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.7667
p.S264L	DO50299	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.7667
p.S264L	DO51253	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.7667
p.S257C	DO222409	MELA	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.1667
p.E268K	DO222595	MELA	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.7022
p.P261L	DO219878	SKCA	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.2778
p.P259Q	DO37707	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.2222
p.P261Q	DO48665	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.2778
p.V275L	DO37991	SKCM	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.1389
p.D276N	DO223286	UCEC	ICGC	PTPNPS	DEG_SCF_FBW7_1	0.1111
p.N255K	SIDM01261	Breast Carcinoma	GDSC	PTPNPS	DEG_SCF_FBW7_1	0.1111
p.N255K	ACH-002208	Breast Cancer	CCLE	PTPNPS	DEG_SCF_FBW7_1	0.1111
p.N255K	YMB-1-E	breast	COSMIC	PTPNPS	DEG_SCF_FBW7_1	0.1111
p.Q254R	SIDM01059	Melanoma	GDSC	PTPNPS	DEG_SCF_FBW7_1	0.0833
p.Q254R	ACH-000915	Skin Cancer	CCLE	PTPNPS	DEG_SCF_FBW7_1	0.0833
p.Q254R	IPC-298	skin	COSMIC	PTPNPS	DEG_SCF_FBW7_1	0.0833
p.H275Y	SIDM01498	Acute Myeloid Leukemia	GDSC	PTPNPS	DEG_SCF_FBW7_1	0.1389
p.H275Y	ACH-000487	Leukemia	CCLE	PTPNPS	DEG_SCF_FBW7_1	0.1389
p.T264I	ACH-002005	Skin Cancer	CCLE	PTPNPS	DEG_SCF_FBW7_1	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPNPS

Degron related mutations and impact score

Drug responses associated with BEND4 mutations

All proteins holding degron of PTPNPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZU67	BEN domain-containing protein 4	DEG_SCF_FBW7_1	263:268	PTPNPS	FBXW7	0.9653	More...