DegronMD

Uniprot ID: Q6ZU67

Source protein: BEN domain-containing protein 4

Source gene: BEND4

Class: DEG_APCC_DBOX_1

Location: 42:50

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.994

ASA_SCORE: 79.9111

COIL: 0.7452

CONS_SCORE: 0.6917

DSS_SCORE: 0.5116

HELIX: 0.0753

FCONS_SCORE: 1.2879

RIG_SCORE: 0.7225

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K39M	TCGA-AD-6895	COAD	TCGA	ERPTLVELP	DEG_APCC_DBOX_1	0.3611
p.L33P	DO225203	BRCA	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	0.1944
p.K35M	DO8938	COAD	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	0.1389
p.P56L	DO227816	COCA	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	0.1667
p.P60L	DO233867	GACA	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	0.0556
p.P53T	DO229037	LICA	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	0.25
p.P52S	DO231518	LINC	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	0.2778
p.P60S	DO229163	THCA	ICGC	ERPTLVELP	DEG_APCC_DBOX_1	0.0556
p.A38D	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	ERPTLVELP	DEG_APCC_DBOX_1	0.2222
p.A38D	ACH-000893	Lung Cancer	CCLE	ERPTLVELP	DEG_APCC_DBOX_1	0.2222
p.R40C	SIDM00217	Colorectal Carcinoma	GDSC	ERPTLVELP	DEG_APCC_DBOX_1	0.2778
p.S32R	ACH-000693	Esophageal Cancer	CCLE	ERPTLVELP	DEG_APCC_DBOX_1	0.0556
p.R36Q	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	ERPTLVELP	DEG_APCC_DBOX_1	0.1667
p.R36Q	T-24	urinary_tract	COSMIC	ERPTLVELP	DEG_APCC_DBOX_1	0.1667
p.G57E	Sarc9371	bone	COSMIC	ERPTLVELP	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZU67	BEN domain-containing protein 4	DEG_APCC_DBOX_1	42:50	ERPTLVELP	APC,CDC20,FZR1	0.994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons