DegronMD

Uniprot ID: Q6ZU67

Source protein: BEN domain-containing protein 4

Source gene: BEND4

Class: DEG_SPOP_SBC_1

Location: 281:285

E3 ligase: SPOP

DEGRON score: 0.8233

ASA_SCORE: 68.46

COIL: 0.869

CONS_SCORE: 0.655

DSS_SCORE: 0.4888

HELIX: 0.0496

FCONS_SCORE: 0.9738

RIG_SCORE: 0.6515

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W293L	TCGA-55-7570	LUAD	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1111
p.L282R	TCGA-66-2734	LUSC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.7316
p.A277T	TCGA-66-2754	LUSC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.2222
p.D280N	TCGA-DF-A2KU	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.3056
p.V279L	TCGA-FR-A3R1	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	0.2778
p.S295F	TCGA-FW-A3R5	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	0.0556
p.S295F	TCGA-ZF-A9R7	BLCA	TCGA	PLSTS	DEG_SPOP_SBC_1	0.0556
p.L282V	TCGA-MA-AA3Z	CESC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.5654
p.S291F	DO219064	BLCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1667
p.S291F	DO37406	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1667
p.L278V	DO219722	CESC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.25
p.H284N	DO229015	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.7423
p.T280N	DO229008	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.W289L	DO25280	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	0.2222
p.P292A	DO25153	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1389
p.L278R	DO26430	LUSC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.25
p.A273T	DO27612	LUSC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.G288S	DO218884	SKCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.25
p.V275L	DO37991	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1667
p.D276N	DO223286	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1944
p.T284A	SIDM00614	Hepatocellular Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T284A	ACH-000848	Liver Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T284A	JHH-7	liver	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.H275Y	SIDM01498	Acute Myeloid Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	0.1667
p.H275Y	ACH-000487	Leukemia	CCLE	PLSTS	DEG_SPOP_SBC_1	0.1667
p.T280A	JHH-7	liver	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00167	Eyes absent homolog 2	DEG_SPOP_SBC_1	196:200	PLSTS	SPOP	0.8269	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	553:557	PLSTS	SPOP	0.8233	More...
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	148:152	PLSTS	SPOP	0.9304	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	214:218	PLSTS	SPOP	0.9858	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	119:123	PLSTS	SPOP	0.6545	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	698:702	PLSTS	SPOP	0.9944	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	345:349	PLSTS	SPOP	0.979	More...
Q70CQ3	Ubiquitin carboxyl-terminal hydrolase 30	DEG_SPOP_SBC_1	466:470	PLSTS	SPOP	0.5113	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	112:116	PLSTS	SPOP	0.7993	More...
Q86Y82	Syntaxin-12	DEG_SPOP_SBC_1	90:94	PLSTS	SPOP	0.702	More...
Q8IY33	MICAL-like protein 2	DEG_SPOP_SBC_1	519:523	PLSTS	SPOP	0.9828	More...
Q8IY92	Structure-specific endonuclease subunit SLX4	DEG_SPOP_SBC_1	1448:1452	PLSTS	SPOP	0.9903	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	2661:2665	PLSTS	SPOP	0.8392	More...
Q8TEQ6	Gem-associated protein 5	DEG_SPOP_SBC_1	850:854	PLSTS	SPOP	0.9922	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	336:340	PLSTS	SPOP	0.9301	More...
Q96Q89	Kinesin-like protein KIF20B	DEG_SPOP_SBC_1	1584:1588	PLSTS	SPOP	0.9863	More...
Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	1046:1050	PLSTS	SPOP	0.6945	More...
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_SPOP_SBC_1	901:905	PLSTS	SPOP	0.9634	More...
Q9H2E6	Semaphorin-6A	DEG_SPOP_SBC_1	1018:1022	PLSTS	SPOP	0.9889	More...
Q9H706	GRB2-associated and regulator of MAPK protein 1	DEG_SPOP_SBC_1	542:546	PLSTS	SPOP	0.9196	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1075:1079	PLSTS	SPOP	0.9851	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	252:256	PLSTS	SPOP	0.7183	More...
Q6ZUB1	Spermatogenesis-associated protein 31E1	DEG_SPOP_SBC_1	1149:1153	PLSTS	SPOP	0.9944	More...
Q96HE9	Proline-rich protein 11	DEG_SPOP_SBC_1	350:354	PLSTS	SPOP	0.9951	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	281:285	PLSTS	SPOP	0.8233	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1617:1621	PLSTS	SPOP	0.5245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSTS

Degron related mutations and impact score

Drug responses associated with BEND4 mutations

All proteins holding degron of PLSTS