DegronMD

Uniprot ID: Q70CQ3

Source protein: Ubiquitin carboxyl-terminal hydrolase 30

Source gene: USP30

Class: DEG_SPOP_SBC_1

Location: 466:470

E3 ligase: SPOP

DEGRON score: 0.5113

ASA_SCORE: 75.74

COIL: 0.8776

CONS_SCORE: 0.4592

DSS_SCORE: 0.3468

HELIX: 0.0682

FCONS_SCORE: 0.9851

RIG_SCORE: 0.6904

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R470C	DO223075	ESCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.8301
p.R470C	DO40851	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.8301
p.R470C	DO41199	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.8301
p.N471S	SIDM00194	Colorectal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.N471S	SIDM00383	Gastric Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.N471S	SIDM00252	Biliary Tract Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.N471S	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.A463T	DO41903	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.25
p.L474P	TCGA-BR-8591	STAD	TCGA	PLSTS	DEG_SPOP_SBC_1	0.2222
p.L474M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	0.2222
p.L474M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.2222
p.D478G	TCGA-A5-A0G2	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1111
p.R458Q	TCGA-EI-6507	READ	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1111
p.R458W	TCGA-V5-A7RE	ESCA	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1111
p.R457Q	TCGA-CG-4440	STAD	TCGA	PLSTS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 15 of 15 entries

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Drug responses associated with USP30 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PLSTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	336:340	PLSTS	SPOP	0.9301	More...
Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	1046:1050	PLSTS	SPOP	0.6945	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	281:285	PLSTS	SPOP	0.8233	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	553:557	PLSTS	SPOP	0.8233	More...
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	148:152	PLSTS	SPOP	0.9304	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	698:702	PLSTS	SPOP	0.9944	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	119:123	PLSTS	SPOP	0.6545	More...
O00167	Eyes absent homolog 2	DEG_SPOP_SBC_1	196:200	PLSTS	SPOP	0.8269	More...
Q8TEQ6	Gem-associated protein 5	DEG_SPOP_SBC_1	850:854	PLSTS	SPOP	0.9922	More...
Q9H706	GRB2-associated and regulator of MAPK protein 1	DEG_SPOP_SBC_1	542:546	PLSTS	SPOP	0.9196	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	252:256	PLSTS	SPOP	0.7183	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	2661:2665	PLSTS	SPOP	0.8392	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	214:218	PLSTS	SPOP	0.9858	More...
Q96Q89	Kinesin-like protein KIF20B	DEG_SPOP_SBC_1	1584:1588	PLSTS	SPOP	0.9863	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	112:116	PLSTS	SPOP	0.7993	More...
Q8IY33	MICAL-like protein 2	DEG_SPOP_SBC_1	519:523	PLSTS	SPOP	0.9828	More...
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_SPOP_SBC_1	901:905	PLSTS	SPOP	0.9634	More...
Q96HE9	Proline-rich protein 11	DEG_SPOP_SBC_1	350:354	PLSTS	SPOP	0.9951	More...
Q9H2E6	Semaphorin-6A	DEG_SPOP_SBC_1	1018:1022	PLSTS	SPOP	0.9889	More...
Q6ZUB1	Spermatogenesis-associated protein 31E1	DEG_SPOP_SBC_1	1149:1153	PLSTS	SPOP	0.9944	More...
Q8IY92	Structure-specific endonuclease subunit SLX4	DEG_SPOP_SBC_1	1448:1452	PLSTS	SPOP	0.9903	More...
Q86Y82	Syntaxin-12	DEG_SPOP_SBC_1	90:94	PLSTS	SPOP	0.702	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1075:1079	PLSTS	SPOP	0.9851	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	345:349	PLSTS	SPOP	0.979	More...
Q70CQ3	Ubiquitin carboxyl-terminal hydrolase 30	DEG_SPOP_SBC_1	466:470	PLSTS	SPOP	0.5113	More...

Showing 1 to 25 of 26 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSTS

Degron related mutations and impact score

Drug responses associated with USP30 mutations

All proteins holding degron of PLSTS