DegronMD - Q70CQ3(USP30)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D478G	TCGA-A5-A0G2	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1111
p.L474P	TCGA-BR-8591	STAD	TCGA	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2222
p.R457Q	TCGA-CG-4440	STAD	TCGA	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0833
p.R458Q	TCGA-EI-6507	READ	TCGA	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1111
p.R458W	TCGA-V5-A7RE	ESCA	TCGA	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1111
p.R470C	DO223075	ESCA	ICGC	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.8301
p.R470C	DO40851	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.8301
p.R470C	DO41199	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.8301
p.A463T	DO41903	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.25
p.L474M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2222
p.L474M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2222
p.N471S	SIDM00194	Colorectal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056
p.N471S	SIDM00383	Gastric Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056
p.N471S	SIDM00252	Biliary Tract Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056
p.N471S	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056

Kaplan plot for USP30 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP30

UniProt ID: Q70CQ3

Entrez ID: 84749

Protein name: Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for USP30 in