DegronMD - Q8IY92(SLX4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1445L	TCGA-55-7913	LUAD	TCGA	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.25
p.R1445L	DO223665	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.25
p.S1266N	TCGA-A5-A2K5	UCEC	TCGA	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation rewiring degron network	0.2778
p.S1266N	DO41379	UCEC	ICGC	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation rewiring degron network	0.2778
p.R1267H	TCGA-A8-A09Z	BRCA	TCGA	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation rewiring degron network	0.25
p.R1267H	DO5521	BRCA	ICGC	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation rewiring degron network	0.25
p.G1447C	TCGA-AA-3715	COAD	TCGA	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.3056
p.G1447C	DO8018	COAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.3056
p.V1106M	TCGA-AX-A1CE	UCEC	TCGA	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation rewiring degron network	0.1111
p.V1106M	DO227802	COCA	ICGC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation rewiring degron network	0.1111
p.V1106M	DO42280	UCEC	ICGC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation rewiring degron network	0.1111
p.A1462T	TCGA-D1-A167	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.0556
p.A1462T	DO40978	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.0556
p.A1461V	TCGA-D3-A3MR	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.0833
p.A1461V	DO47256	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.0833
p.K1120Q	TCGA-D9-A6EC	SKCM	TCGA	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation blocking ubiquitination signal	0.75
p.K1120Q	DO50291	SKCM	ICGC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation blocking ubiquitination signal	0.75
p.P1261S	TCGA-EE-A2MS	SKCM	TCGA	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation altering degron motif	0.6752
p.P1261S	DO37567	SKCM	ICGC	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation altering degron motif	0.6752
p.E1247K	TCGA-EI-7004	READ	TCGA	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation rewiring degron network	0.0556
p.E1247K	DO36507	READ	ICGC	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation rewiring degron network	0.0556
p.P1261Q	TCGA-ER-A19F	SKCM	TCGA	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation altering degron motif	0.7035
p.P1261Q	DO37679	SKCM	ICGC	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation altering degron motif	0.7035
p.M1116V	DO230326	COCA	ICGC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation altering degron motif	0.6097
p.P1122L	DO229003	COCA	ICGC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation rewiring degron network	0.25
p.P1122L	DO229505	LAML	ICGC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation rewiring degron network	0.25
p.S1271F	DO228941	LICA	ICGC	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation blocking phosphorylation signal	0.5833
p.R1456S	DO229015	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.2222
p.A1248D	DO229025	LICA	ICGC	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation rewiring degron network	0.0833
p.T1260P	DO52352	LUSC	ICGC	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation altering degron motif	0.8142
p.T1260P	DO50659	ORCA	ICGC	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation altering degron motif	0.8142
p.Q1128L	DO231204	LUSC	ICGC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation rewiring degron network	0.0833
p.P1122S	SIDM00545	Melanoma	GDSC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation rewiring degron network	0.25
p.P1122S	ACH-000987	Skin Cancer	CCLE	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation rewiring degron network	0.25
p.P1122S	Mewo	skin	COSMIC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation rewiring degron network	0.25
p.S1123P	SIDM00589	Oral Cavity Carcinoma	GDSC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation blocking phosphorylation signal	0.6667
p.S1123P	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation blocking phosphorylation signal	0.6667
p.S1123P	SIDM00167	Head and Neck Carcinoma	GDSC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation blocking phosphorylation signal	0.6667
p.S1123P	SIDM01611	Endometrial Carcinoma	GDSC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation blocking phosphorylation signal	0.6667
p.S1123P	RC-K8	haematopoietic and lymphoid tissue	COSMIC	VLMFPE	LIG_APCC_ABBA_1	1114:1119	Mutation blocking phosphorylation signal	0.6667
p.R1456P	SIDM00002	Neuroblastoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.2222
p.R1456P	ACH-002340	Neuroblastoma	CCLE	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.2222
p.R1456P	NBsusSR	autonomic ganglia	COSMIC	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.2222
p.S1249N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation rewiring degron network	0.1111
p.S1249N	ACH-002222	Leukemia	CCLE	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation rewiring degron network	0.1111
p.S1249N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	VPATPLAS	DEG_SCF_FBW7_1	1257:1264	Mutation rewiring degron network	0.1111
p.A1462V	SIDM01750	Melanoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.0556
p.A1462V	ACH-000801	Skin Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.0556

Kaplan plot for SLX4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLX4

UniProt ID: Q8IY92

Entrez ID: 84464

Protein name: Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLX4 in